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Controversies in glycaemia management. Implications of recent trials: ADVANCE, VADT, ACCORD, UKPDS
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Continuous relationship between HbA1c in whole population (male participants-EPIC Norfolk)
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UKPDS 35: Significant Risk Reduction for T2DM Complications with Each 1% Reduction in Mean HbA1c
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UKPDSextension-CVbenefitsobserveddespitenosignificantdifferencesinHbA1cduringFU
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ClassIrecommendation
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Dia 6
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Methods 1
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10 trials screened and 5 trials included
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Methods
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Baseline characteristics
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Treatment regimen
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Endpoints
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EffectofmorevslessintensivecontrolofglucoseonNF-MI
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EffectofmorevslessintensivecontrolofglucoseonCHD
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Effectofmorevslessintensivecontrolofglucoseonstroke
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Effectofmorevslessintensivecontrolofglucoseondeath
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EffectofmorevslessintensivecontrolofglucoseonHF
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Comparisonofeffectofmoreintensiveglycaemiccontrolonclinicaloutcomesinstudieswithavailableinformationontheseoutcomes*
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Adverse events
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Benefit of different interventions per 200 diabetic pts treated for 5 years
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Benefit of different interventions per 200 diabetic pts treated for 5 years
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Benefit of different interventions per 200 diabetic pts treated for 5 years
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TurnbulletalDiabetalogia2009
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ManuccietalNutMetCVdisease2009
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Conclusion 1
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Conclusion 2
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Future trials
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