Physicians' Academy for Cardiovascular Education

slides dr farnier

Slides (presentation) - Jan. 9, 2010

The clinical significance of lipid-lowering through liver and intestine: An overview of all relevant data for atherosclerosis
Prof. Michel Farnier: Biography
Lipid-loweringthroughliverandintestine
Background
EuropeanGuidelines
MetabolismofApoB-containingLPs
Effects of Ezetimibe and Simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia
RegulationofInVivoMetabolismofApoB-containingLPsbyEzetimibe
RegulationofInVivoMetabolismofApoB-containingLPsbySimvastatin
RegulationofInVivoMetabolismofApoB-containingLPsbyEze+Simva
Methodsofmeasuringcholesterolabsorptionandproduction
AbsorptionandSynthesisMarkers
Factors affecting cholesterol absorption and production
Are baseline synthesis and absorption markers predictive of response to treatment and of LDL-C changes ?
Post-hocanalysisoftheSTELLARandENHANCEtrials
Does Ezetimibe-mediated inhibition of cholesterol absorption induce increase in cholesterol synthesis ?
EffectsofEzetimibeonintestinalabsorptionandcholesterolsynthesis
Does Statin-mediated inhibition of cholesterol synthesis induce increase in cholesterol absorption ?
Statintreatmentsinduceincreasesinmarkersofabsorption
ComparisonoftheEffectsofMaximalDoseAtorvastatinandRosuvastatinTherapyonCholesterolSynthesisandAbsorptionMarkers:apost-analysisofSTELLARTrial
ENHANCE:Post-hocanalysis
ENHANCE:Post-hocanalysis
Conclusionforclinicalpractice
Treatment options for a high-risk patient not at LDL-C goal on statin therapy
EffectsofstatinsonHDL-CandLDL-C:resultsfromtheVOYAGERdatabase(32258patients)
WorkingHypothesis
IN-CROSSStudy:StudyDesign
IN-CROSSStudy:Primaryend-point
IN-CROSSStudy:primaryend-pointinpatientswithandwithoutT2DM
IN-CROSSStudy:%ofPatientsReachingLDL-CGoalsatStudyEndpoint
IN-PRACTICE:StudyDesign
IN-PRACTICE:Primaryefficacyendpoint
IN-PRACTICE:Secondaryefficacyendpoint
EzetimibeaddedontoAtorvastatin(20mg)vsUptitrationofAtorvastatin(to40mg)inHypercholesterolemicpatientsatModeratelyHighRiskforCHD(TEMPO)
EzetimibeaddedontoAtorvastatin(20mg)vsUptitrationofAtorvastatin(to40mg)inHypercholesterolemicpatientsatModeratelyHighRiskforCHD(TEMPO)
EzetimibeaddedontoAtorvastatin(40mg)vsUptitrationofAtorvastatin(to80mg)inHypercholesterolemicpatientsatHighRiskforCHD(EZ-PATH)
EzetimibeaddedontoAtorvastatin(40mg)vsUptitrationofAtorvastatin(to80mg)inHypercholesterolemicpatientsatHighRiskforCHD(EZ-PATH)
Ezetimibe/Simvastatin;efficacyinspecialpopulations
EzetimibeandSimvastatininAdolescentswithHeFH
EzetimibeandSimvastatininAdolescentswithHeFH
EzetimibeiswelltoleratedandeffectiveincombinationwithstatintherapyinHIV-infectedpatients
Efficacy and Tolerability of Ezetimibe in Cardiac Transplant Recipients Taking Cyclosporin
Ezetimibe:MechanismofAction
Beyond LDL Lowering Effects
EffectsofEze10mgandSimva40mg,CoadministeredandAloneonapoBmetabolisminmaleswithmixedhyperlipidemia
EffectsofEze10mgandSimva40mg,CoadministeredandAloneonapoBmetabolisminmaleswithmixedhyperlipidemia
EffectsofEze10mgandSimva40mg,CoadministeredandAloneonapoBmetabolisminmaleswithmixedhyperlipidemia
Conclusions (1)
Conclusions (2)

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