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Diabetes and Hypertension
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Global Mortality 2000: Impact of hypertension and other health risk factors
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Hypertension:SizeoftheProblem-GlobalProspects
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Globalprojectionsfordiabetes(millions)2007-2025
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Management of hypertension: the issues
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Measurement
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Management of hypertension: the issues
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Absolute Risk of CVD Over 5 Years in Patients by Systolic Blood Pressure at Specified Levels of Other Risk Factors*
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ESH-ESCGuidelines2007
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Non-diabetic Men
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Dia 11
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Management of hypertension: the issues
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Lifestylemeasures:BHSIV
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Management of hypertension: the issues
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BPtreatmentthreshold
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ESH-ESCGuidelines2007
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Management of hypertension: the issues
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First-line therapy
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UK Prospective Diabetes Study
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Lessons from UKPDS
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Subgroups:AmlodipinevsChlorthalidone
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Subgroups:LisinoprilvsChlorthalidone
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Multiple Antihypertensive Agents are Needed to Reach BP Goal
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“Monotherapyisusuallyinadequatetherapy”BHSIV
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ESH-ESCGuidelines2007Treatmentalgorithms
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2007ESH/ESCGuidelinesCombinationbetweensomeclassesofantihypertensivedrugs
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Choosingdrugsforpatientsnewlydiagnosedwithhypertension:NICE/BHS
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Interpretation
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Managementofhypertensioninpatientswithdiabetes
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A + D induces more New-Onset Diabetes than A + C
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New-onsetdiabetesmellitus
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Event rates (per 1000 pyrs) according to glycaemic status after 1 year from randomisation
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Placebo-controlled trials and NOD
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Diabetologic potential of antihypertensive agents: Summary
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ACCOMPLISH: Design
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Primary and Other Endpoints
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Management of hypertension: the issues
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BP Targets
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BP Targets in Various Guidelines
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Effects of Antihypertensive Drug Treatment on SBP in Hypertensive Patients With Diabetes
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Significant Benefits From Intensive Blood Pressure Reduction in Diabetics (HOT)
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[Stroke]
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:MajorCVevents
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Dia 45
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Randomised study treatments
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Blood pressure reduction
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Summary
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ADVANCEincontext:UKProspectiveDiabetesStudy
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Management of hypertension: the issues
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Recentguidelinesforlipidloweringinpatientswithhypertension‘Thresholds’in1oprevention
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