Physicians' Academy for Cardiovascular Education

Managing blood pressure & the Kidney in diabetes

Slides (presentation) - Jan. 18, 2011

MANAGING BLOOD PRESSURE (& THE KIDNEY?) IN DIABETES
Global Mortality 2000: Impact of hypertension and other health risk factors
Hypertension:SizeoftheProblem-GlobalProspects
Globalprojectionsfordiabetes(millions)2007-2025
Management of hypertension: the issues
Measurement
Management of hypertension: the issues
Absolute Risk of CVD Over 5 Years in Patients by Systolic Blood Pressure at Specified Levels of Other Risk Factors*
Dia 9
Management of hypertension: the issues
Lifestylemeasures:BHSIV
Management of hypertension: the issues
BPtreatmentthreshold
Management of hypertension: the issues
First-line therapy
Dia 16
Interpretation
UK Prospective Diabetes Study
Lessons from UKPDS
Subgroups:AmlodipinevsChlorthalidone
Subgroups:LisinoprilvsChlorthalidone
Diabetologic potential of antihypertensive agents: Summary
“Monotherapyisusuallyinadequatetherapy”BHSIV
Choosingdrugsforpatientsnewlydiagnosedwithhypertension:NICE/BHS
Managementofhypertensioninpatientswithdiabetes
ACCOMPLISH: Design
ACCOMPLISH: Effects on Primary and Other End points
A Personal View of Optimal Antihypertensive Drug Sequencing
RENAL CONSIDERATIONS
ONTARGET
ON-TARGETTrial:(27)Kaplan-MeierCurvesforthePrimaryOutcome*
ONTARGET Trial: Effects on major outcomes
Management of hypertension: the issues
BP Targets in Various Guidelines
Effects of Antihypertensive Drug Treatment on SBP in Hypertensive Patients With Diabetes
Significant Benefits From Intensive Blood Pressure Reduction in Diabetics (HOT)
[Stroke]
:MajorCVevents
ADVANCEincontext:UKProspectiveDiabetesStudy
Effect of intensive glycemic control on CV outcomes in patients with T2D
ACCORD:SBPChanges
ACCORD Results
Percent reduction of cardiovascular endpoints in the UKPDS
Management of hypertension: the issues
Conclusions

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