Physicians' Academy for Cardiovascular Education

Obesity & pre diabetes: Mechanisms linking fat to CV disease

Slides (presentation) - Jan. 18, 2011

Obesity & Prediabetes: Mechanisms linking fat to CV disease
Inflammation, Obesity, Diabetes and Cardiovascular Disease
Acute inflammation
Chronic inflammation
Excess Adipose Tissue Can Cause Increased Expression of Some Hormones and the Suppression of Others and Can Lead to Inflammation and Disease
Evidence for Inflammatory Activation in Obesity in Humans
Other factors contributing to chronic inflammation
Cytokines
Adipocytokines
Adiponectin
Adiponectin
CRP
Obesity and CRP Levels: NHANES 1988-1994
Differences Between Visceral (VAT) And Subcutaneous (SAT) Adipose Tissue
Is the “Inflammation” of Obesity More than an Epiphenomena?
Fat distribution and inflammation in men and women in the KORA Study
Central adiposity and inflammatory markers in men in the ATTICA study
Genetic polymorphisms that increase cytokines promote diabetes
Obesity, Inflammation and Metabolic Syndrome
Liposuction and metabolic function
Effect of weight loss and steady state reduced fat mass on inflammatory markers
Obesity,inflammationandandcardiovasculardisease
Lifestyle
Conclusions
Classical view of adipose tissue
Metabolic Profiles of Two Subgroups of Obese Men Matched for Age and % Body Fat
Most fat is healthy
‘Ectopic’Fat
Inflammation and Atherosclerosis
Unifying model: from endothelial dysfunction to CV disease
RelationshipbetweenadiponectinandPAI-1inoverweightorobesewomen(2)
Adipose tissue: production of substrates, cytokines and hormones
Obesity, Inflammation and diabetes
Hypothetical interaction of obstructive sleep apnea syndrome and obesity in activating pathways leading to metabolic disease
Shared inflammatory pathways associated with obesity and obstructive sleep apnea syndrome and increased cardiovascular disease risk
Summary of Adipose Tissue Dysfunction in Obesity

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