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Obesity & Prediabetes: Mechanisms linking fat to CV disease
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Inflammation, Obesity, Diabetes and Cardiovascular Disease
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Acute inflammation
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Chronic inflammation
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Excess Adipose Tissue Can Cause Increased Expression of Some Hormones and the Suppression of Others and Can Lead to Inflammation and Disease
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Evidence for Inflammatory Activation in Obesity in Humans
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Other factors contributing to chronic inflammation
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Cytokines
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Adipocytokines
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Adiponectin
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Adiponectin
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CRP
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Obesity and CRP Levels: NHANES 1988-1994
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Differences Between Visceral (VAT) And Subcutaneous (SAT) Adipose Tissue
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Is the “Inflammation” of Obesity More than an Epiphenomena?
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Fat distribution and inflammation in men and women in the KORA Study
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Central adiposity and inflammatory markers in men in the ATTICA study
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Genetic polymorphisms that increase cytokines promote diabetes
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Obesity, Inflammation and Metabolic Syndrome
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Liposuction and metabolic function
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Effect of weight loss and steady state reduced fat mass on inflammatory markers
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Obesity,inflammationandandcardiovasculardisease
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Lifestyle
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Conclusions
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Classical view of adipose tissue
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Metabolic Profiles of Two Subgroups of Obese Men Matched for Age and % Body Fat
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Most fat is healthy
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‘Ectopic’Fat
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Inflammation and Atherosclerosis
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Unifying model: from endothelial dysfunction to CV disease
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RelationshipbetweenadiponectinandPAI-1inoverweightorobesewomen(2)
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Adipose tissue: production of substrates, cytokines and hormones
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Obesity, Inflammation and diabetes
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Hypothetical interaction of obstructive sleep apnea syndrome and obesity in activating pathways leading to metabolic disease
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Shared inflammatory pathways associated with obesity and obstructive sleep apnea syndrome and increased cardiovascular disease risk
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Summary of Adipose Tissue Dysfunction in Obesity
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