Obesity & pre diabetes: Mechanisms linking fat to CV disease

Obesity & Prediabetes:Mechanisms linking fat to CV disease	Inflammation, Obesity, Diabetes and Cardiovascular Disease
Acute inflammation	Chronic inflammation
Excess Adipose Tissue Can Cause Increased Expression of Some Hormones and the Suppression of Others and Can Lead to Inflammation and Disease	Evidence for Inflammatory Activation in Obesity in Humans
Other factors contributing to chronic inflammation	Cytokines
Adipocytokines	Adiponectin
Adiponectin	CRP
Obesity and CRP Levels: NHANES 1988-1994	Differences Between Visceral (VAT) AndSubcutaneous (SAT) Adipose Tissue
Is the “Inflammation” of Obesity More than an Epiphenomena?	Fat distribution and inflammation in men and women in the KORA Study
Central adiposity and inflammatory markers in men in the ATTICA study	Genetic polymorphisms that increase cytokines promote diabetes
Obesity, Inflammation and Metabolic Syndrome	Liposuction and metabolic function
Effect of weight loss and steady state reduced fat mass on inflammatory markers	Obesity,inflammationandandcardiovasculardisease
Lifestyle	Conclusions
Classical view of adipose tissue	Metabolic Profiles of Two Subgroups of Obese Men Matched for Age and % Body Fat
Most fat is healthy	‘Ectopic’Fat
Inflammation and Atherosclerosis	Unifying model: from endothelial dysfunction to CV disease
RelationshipbetweenadiponectinandPAI-1inoverweightorobesewomen(2)	Adipose tissue: production of substrates, cytokines and hormones
Obesity, Inflammation and diabetes	Hypothetical interaction of obstructive sleep apnea syndrome and obesity in activatingpathways leading to metabolic disease
Shared inflammatory pathways associated with obesity and obstructive sleep apnea syndrome and increased cardiovascular disease risk	Summary of Adipose Tissue Dysfunction in Obesity

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