Physicians' Academy for Cardiovascular Education

Cholesterol absorption

Slides (presentation) - Mar. 24, 2011

New Approaches to LDL Reduction
Cholesterol Absorption Inhibitors

Teaching slides on new approaches to lower LDL cholesterol

Update April 2011


New Approaches to LDL Reduction
Inhibition of Cholesterol Absorption and Production With Ezetimibe/Simvastatin
Cholesterol Balance in Mice (µmol/day.100 g body wt)
Ezetimibe strongly increases TICE
Cholesterol Fluxes in Humans(mg/day.70 kg body wt)
Next Steps
ENHANCE
ENHANCE - Logical Next Step After ASAP -
ENHANCE Study Population
ENHANCE Study Design
Baseline Characteristics
LDL-Cholesterol
ENHANCE hsCRP
Possible Explanations for the Absence of an Incremental Reduction in cIMT
The Trial Design and Population
Critical Factors for Successful cIMT Trial
Critical Factors for Successful cIMT Trial
ASAP and ENHANCE Baseline cIMT in LIPID (Pediatric)
Conclusion from ENHANCE

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