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New Approaches to LDL Reduction
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Inhibition of Cholesterol Absorption and Production With Ezetimibe/Simvastatin
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Cholesterol Balance in Mice (µmol/day.100 g body wt)
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Ezetimibe strongly increases TICE
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Cholesterol Fluxes in Humans(mg/day.70 kg body wt)
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Next Steps
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ENHANCE
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ENHANCE - Logical Next Step After ASAP -
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ENHANCE Study Population
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ENHANCE Study Design
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Baseline Characteristics
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LDL-Cholesterol
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ENHANCE hsCRP
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Possible Explanations for the Absence of an Incremental Reduction in cIMT
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The Trial Design and Population
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Critical Factors for Successful cIMT Trial
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Critical Factors for Successful cIMT Trial
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ASAP and ENHANCE Baseline cIMT in LIPID (Pediatric)
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Conclusion from ENHANCE
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PPT Cholesterol absorption (PPTX 1.6MB)
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