Physicians' Academy for Cardiovascular Education

Targeting blood pressure:

Slides (presentation) - May 7, 2011

Targeting Blood Pressure:
What are the Optimal Targets in CV Risk and Diabetes?


Gordon McInnes, MD
Professor of Clinical Pharmacology
University of Glasgow,
Western Infirmary
Glasgow, United Kingdom

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The concept of Diabetes & CV risk: A lifetime risk challenge
Global Mortality 2000: Impact of Correctable Risk Factors
Meta-analysis of individual Blood Pressure data for 1million adults in 61 prospective studies Prospective Studies Collaboration Lancet 2002 360 1903
Diabetes – CHD Risk Equivalent
Benefits of antihypertensive treatment proportional to reduction in blood pressure
Benefits of Antihypertensive Treatment Absolute Risk Reduction
UKPDS : Tight Glucose vs Tight BP Control and CV Outcomes in UKPDS
HOT Study:
Slide 9
Hypertension Optimal Treatment (HOT) Study
UKPDS: Microvascular Endpoints, MI, and SBP
Reduced blood pressure slows the rate of GFR decline
More Versus Less Intensive BP Control Meta-analysis : RR
Blood Pressure Targets
INVEST: Incidence of Myocardial Infarction (MI) and Stroke by Diastolic Blood Pressure Strata
ESH guidelines - Reappraisal
Recommendations for BP Goals
ADVANCE: Primary Outcomes
ADVANCE & ACCORD in context - UKPDS
Risk of Stroke in DM or Impaired FBS

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