Physicians' Academy for Cardiovascular Education

The importance of lipid lowering through liver and intestine:

Slides (presentation) - May 28, 2011

The importance of lipid lowering through liver and intestine:
An overview of all relevant data for atherosclerosis


Dr. Kees Hovingh, MD
Academic Medical Centre,
Amsterdam , The Netherlands
MC Lipid Innovations - May 2011



Click on slides to view presentation


Master Class Lipid Innovations Prague, Czech Republic May 27-28, 2011
Statins : Corner Stone
Statins: Effect on CAD Risk
However......
Cholesterol balance (µmol/day.100 g body wt) in mice
Ezetimibe strongly increases TICE
Cholesterol fluxes (mg/day.70 kg body wt) in man
Statin Effect on Cholesterol Absorption and Production
Ezetimibe Effect on Cholesterol Absorption and Production
Ezetimibe/Simvastatin Dual Action
Ezetimibe + Statin = Reduced Cholesterol Absorption and Production
LDL-C–Lowering
Ezetimibe + Simvastatin Superior Goal Attainment
Different statin, ... similar result
Effects of Rosuvastatin + Ezetimibe
Laboratory Values: Muscle and Liver
ENHANCE
ENHANCE
ASAP vs ENHANCE
Conclusions

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