Physicians' Academy for Cardiovascular Education

Vascular function as an early sign of trouble:

Slides (presentation) - May 28, 2011

Vascular function as an early sign of trouble:
How can the inhibition of cholesterol absorption reduce the atherogenic load of intestinal lipoproteins?

Prof. Frank Visseren, MD
Academic Medical Centre Utrecht
The Netherlands
MC Lipid Innovations - Prague - May 2011



Click on slides to view presentation


Overview of Cholesterol Transport
Cholesterol transporter
Postprandial lipidemia
Copenhagen City Heart Study
Triglyceride levels and levels of remnant lipoprotein cholesterol
Levels of Remnant Lipoprotein Cholesterol
Non-fasting triglycerides and risk for MI, IHD and death in Women
Non-fasting triglycerides and risk for MI, IHD and death in Men
Women’s Health Study (WHS)
Association of triglyceride levels with incident CVD
Womens Health Study (WHS)
Triglyceride concentrations
Drop in HDL-c after an oral fatload
Increase in Cholesterol Ester Transfer (CET) after an oral fatload
Oral Triglyceride Tolerance Test!??
Effect of statin versus fibrate
Ezetimibe improves postprandial hyperlipemia
Ezetimibe improves postprandial hyperlipemia
Low-dose statin and ezetimibe compared to high-dose simvastatin on
Low-dose statin and ezetimibe compared to high-dose simvastatin
Low-dose statin and ezetimibe compared to high-dose simvastatin on
Low-dose statin and ezetimibe compared to high-dose simvastatin on
Conclusions
The PANACEA Study
The PANACEA Study
The PANACEA Study
PANACEA trial design
Conclusions

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