Physicians' Academy for Cardiovascular Education

Genes for CV prediction & treatment: Fact or Fiction?

Slides (presentation) - June 17, 2011

Genes for CV prediction & treatment: Fact or Fiction?

Prof. Steve Humphries
University College London


View presentation, click on slides below


Clinical utility in UK for CRF risk prediction
NORTHWICK PARK HEART STUDY II
RISK SCORE METHODS - PROCAM/Framingham
CRFs Predict Poorly in UK Middle-Aged Men
CRP : Origin, Clearance and Function
Adding CRP to algorithm Risk Score in NPHSII
Will genotype predict risk over-and-above trait
Genome Wide Scans – case control approach
Major New “Gene” for MI/CHD Identified on Chromosome 9
Is Chr9 SNP CHD risk effect robust?
ROC to test predictive power
Chr9 SNP and Risk Prediction in NPHSII men
SEVEN GWAS SNPs FOR CHD RISK IDENTIFIED
Current CHD GWAS loci
Combining Modest-Risk Genotypes – Gene Score
Distribution of Risk alleles in NPHSII men
Where is the rest of the Genetic contribution ?
ELSI - Risk Perception and Behaviour Change
CARE PATHWAY FOR CARDIOVASCULAR RISK CLINIC
A CVD-Risk DNA Test : Fact

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