Physicians' Academy for Cardiovascular Education

HDL C concentration versus HDL particle function

Slides (presentation) - Oct. 18, 2011

Prof. Ulf Landmesser
University Hospital Zürich
Zürich, Switzerland

To view presentation, click on slides below


HDL-C concentration versus HDL particle function: What exactly does HDL functionality mean?
Acute coronary syndromes result most frequently from coronary plaques without significant stenosis
Intensive vs. moderate statin therapy and coronary disease
Low HDL remains a predictor of cardiovascular risk in statin-treated patients
HDL – a novel target in coronary disease ?
Atherosclerosis development: Dysbalance between increased foam cell formation and impaired HDL-dependent cholesterol efflux from lipid-laden macrophages
HDL-C concentration versus HDL particle function: What exactly does HDL functionality mean?
HDL: proposed anti-atherogenic effects
HDL-mediated regression of atherosclerosis in cholesterol-fed rabbits
Increased atherosclerosis in ABCA-1 /ABCG1 bone-marrow-deficient mice
HDL: proposed anti-atherogenic effects
Vasculoprotective effect of HDL: role of nitric oxide (NO)
Endothelial NO production – Anti-atherogenic effects
Endothelial dysfunction, nitric oxide, and coronary atherosclerosis
HDL-C concentration versus HDL particle function: What exactly does HDL functionality mean?
Effect of HDL on endothelial cell nitric oxide production in CAD ?
Endothelial effects of HDL in patients with stable coronary disease or acute coronary syndrome as compared to healthy subjects ?
Study design: Endothelial effects of HDL - endothelial bioassays
Characteristics of the study population
HDL -endothelial effects in patients with coronary disease
HDL –effects on endothelial cell nitric oxide production in patients with CAD
Effects of HDL on vascular inflammation: monocyte adhesion on TNFα-stimulated endothelial cells
Carotid injury model to examine in vivo endothelial repair capacity of HDL
Effects of HDL on endothelial repair after arterial injury
HDL function (vascular effects) Which changes of HDL are mediating differences in HDL‘s vascular effects ?
The complexity of the HDL-lipoprotein
HDL-associated paraoxonase activity and content
HDL from paraoxonase-deficient mice fails to stimulate endothelial NO production
Mechanisms leading to HDL dysfunction with respect to effects on endothelial nitric oxide
Effects of HDL on endothelial apoptosis are eNOS-independent
Changes of HDL proteome in coronary disease
Effects of HDL from type-2 diabetics on endothelial NO-Production is impaired
Impaired endothelial effects of HDL in patients with antiphospholipid syndrome
Cholesterol efflux capacity of ApoB-depleted serum and coronary disease
Leducq Transatlantic Network: HDL dysfunction in the pathophysiology in cardiovascular disease and as a novel treatment target
HDL-C concentration versus HDL particle function: What exactly does HDL functionality mean?
HDL metabolism – potential targets ?
HDL in genome-wide association studies
HDL metabolism – potential targets ?
Summary

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