Physicians' Academy for Cardiovascular Education

Structural and functional imaging

Slides (presentation) - Oct. 18, 2011

Prof. Robin Choudhury
John Radcliffe Hospital
Oxford, United Kingdom 

To view presentation, click on slides below


De-risking the development programs of CETP inhibitors after the torcetrapib failure: Structural & functional imaging
Overview
Modalities for atherosclerosis imaging
Imaging the vessel wall in atherosclerosis
Atherosclerosis regression on statins – wall imaging with MRI
Plaque composition analysis
ASTEROID – Potential for plaque regression with IVUS
IVUS – pooled data suggests regression “tipping point”
HDL-cholesterol relationship persists in patients treated with statins
Effect of nicotinic acid on atherosclerosis progression when added to statin therapy
Carotid plaque imaging – multi-contrast MRI
Vascular FUNCTION – aortic pulse wave velocity and compliance
Brachial artery flow-mediated vasodilatation
Patient flow
Effect of nicotinic acid on lipoproteins
Effect of nicotinic acid on atherosclerosis progression
Lipoproteins in relation to changes in vessel wall area
18FDG-PET response to 3 months statin treatment
18FDG PET signal correlates with macrophage content
18FDG-PET – plaque measurement parameters
De-risking ‘challenges’ for imaging
“Failure of Torcetrapib”
“Failure of Torcetrapib”
dal-PLAQUE
Dal-PLAQUE rationale
Dal-PLAQUE
Dal-PLAQUE: design
Dal-PLAQUE: inclusion
Dal-PLAQUE: end points
Dal-PLAQUE: baseline characteristics
Dal-PLAQUE: baseline characteristics
Dal-PLAQUE: MRI (24 months) and PET (6 months) outcomes
Dal-PLAQUE: MRI (24 months): change in total vessel area
Dal-PLAQUE: MRI (24 months): change in total vessel area
Dal-PLAQUE: PET-CT (6 months): change in target to background ratio in most diseased segment
Dal-PLAQUE: PET-CT (6 months): change in target to background ratio in most diseased segment
Dal-PLAQUE: PET-CT (6 months): change in target to background ratio in most diseased segment by HDL-c tertile
Dal-PLAQUE: effect on plasma lipids
Dal-PLAQUE: effect on inflammatory markers
Dal-PLAQUE: “safety” variables
Dal-PLAQUE: summary
Conclusions
Conclusions

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