Physicians' Academy for Cardiovascular Education

The epidemiology of HDL-C and CV disease: Does HDL protect against atherosclerotic events?

Slides (presentation) - Oct. 18, 2011

Dr. Kees Hovingh
Academic Medical Centre
Amsterdam, The Netherlands

To view presentation, click on slides below



The epidemiology of HDL-C and cardiovascular disease: Does HDL indeed protect against atherosclerotic events?
LDL lowering
Statins effect on CAD risk
Low HDL-C and CVD risk
TNT: Events in HDL-C and LDL-C quintiles
Why does HDL-C protect?
HDL-C
Reverse Cholesterol
Production, maturation and metabolism of HDL
When serum induces more efflux, prognosis is worse
ApoA-I is the major protein
Heterozygosity for ApoAIL178P biochemistry
Heterozygosity for ApoA-IL178P event-free survival in carriers vs non-carriers
ApoAI based therapies
Production, maturation and metabolism of HDL
ABCAI heterozygotes and endothelial dysfunction
ABCAI heterozygotes and risk for CAD
Results
Results-increased outward
Results-more plaque
Conclusions

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