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Mechanisms in chronic kidney disease
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Chronic Kidney Disease & Mineral Bone Disorder
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Where is the initial “push” as GFR declines?
At what are the early adaptive responses aimed?
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Where is the initial “push” as GFR declines?
At what are the early adaptive responses aimed?
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Phosphate: the achilles heel of
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Relationship Between GFR and TRP
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Effect of Dietary Phosphate Restriction on PTH
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“Trade-off”
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Phosphate is a poor marker for SHPT in early CKD
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Fibroblast Growth Factor-23 in Early Chronic Kidney Disease
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Progression of SHPT: parathyroid hyperplasia
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Impaired calcium sensing in SHPT
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Calcimimetic Compounds Increase theSensitivity of the CaR to Calcium
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PTH-Ca curve obtained before and after calcimimetic therapy
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1,25-dihydroxyvitamin D not only a hormone
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1,25(OH)2D3 and 25(OH)D3 deficiency and SHPT SEEK study
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25-hydroxyvitamin D3 suppresses PTH synthesis
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PT Injection with 22-oxacalcitriol
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Slide 21
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Regulation of calcitriol production by phosphate
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Regulation of calcitriol production by phosphate
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Phosphate restriction/supplementation in paediatric CKD
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Adaptive responses are often more striking than the initial perturbation
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Adaptive responses are often more striking than the initial perturbation
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