Physicians' Academy for Cardiovascular Education

The importance of lipid lowering through liver and intestine

Slides (presentation) - Oct. 7, 2012

The importance of lipid lowering through liver and intestine: An overview of all relevant data for atherosclerosis

Selection of slides prepared & presented by:
Prof. Alberto Corsini, PhD, Department of Pharmacological Sciences, University of Milan, Milan, Italy
at PACE Lipid Master Class
Budapest, September 21-22, 2012
The importance of lipid lowering through liver and intestine
Factors affecting the response to statins
Risk:Benefit Ratio of Statin Titration
Muscular symptoms
Preiss D et al
Individual responses of lipids
Lathosterol and campesterol changes
Correlation of the synthesis and absorption
Dual Inhibition: Ezetimibe and Statin
As high as 60% LDL-C lowering
Consistency of Co-Administration Studies
Eze + Rosuva vs Rosuva Uptitration
Rosuva 5 mg and 10 mg + Ezetimibe
Attainement of pre-specified LDL-C
Pooled-analysis of 27 clinical trials
Ezetimibe alone and in combination lowers
Effect of Atorvastatin 20 mg and Atorvastatin/Ezetimibe 5/5 mg
The non alcoholic fatty liver disease (NAFLD)
The sine qua non of fatty liver disease
Proposed mechanisms for NPC1L1 deficiency
Effects of low-dose simvastatin and ezetimibe
Low dose Simvastatin and Eze
Effect of Ezetimibe on carotid plaque burden
Effect of Ezetimibe on carotid plaque burden
Journal of Cardiology 158 (2012) 400–404
Percentual changes of LDL-C
Take home messages

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