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Novel therapies
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Novel Approaches to Modify Lipids and Lipoproteins
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Statin Prescription in the UK
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Percentage of the UK-population
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All-Cause Mortality in the UK
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New Approaches to LDL Reduction
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New Approaches to LDL Reduction
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Heterozygous Familial Hypercholesterolemia
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Mipomersen Significantly Reduced LDL-C
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Distribution of LDL-C %
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MTPIs – Efficacy comes
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AEGR 733HoFH Phase II Study Design
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Change in Lipids Using Lomitapide
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HoFH Phase 3: 6-Month Lipid Efficacy
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LDL Receptor Function and Life Cycle
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The Role of PCSK9
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Impact of an Anti-PCSK9
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Study Design REGN727
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Changes in LDL-C
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Change in Calculated LDL-C
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Attainment of Prespecified LDL-C
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Novel Approaches to Modify Lipids
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New Approaches for Raising HDL
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The Dal-HEART Program
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25
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Effects on LDL-C and HDL-C
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Adjudicated CV Events and Death
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Adjudicated CV Events and Death
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Future
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New Approaches for LDL and HDL
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ApoA1 Based Therapies
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New Approaches for Reduction ofTG
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Conclusion
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