Physicians' Academy for Cardiovascular Education

2014: the major lipid developments in review

Dec. 20, 2014 - Amsterdam - Prof. John JP Kastelein

Prof. John Kastelein, Amsterdam, (PACE director) reviews the major news from 2014 on the 3 lipoproteins: LDL-c, HDL-c and TG that provide new understanding and implications for the fight against atherosclerosis.

Key take home messages:
  • TG rich lipoprotein causal in pathway for atherogenesis, and target for therapy
  • End of HDL-c hypothesis and start of Cholesterol Efflux capacity (confirmed by HDL-c)
  • Prove of LDL-c lowering hypothesis with non statin therapy by IMPROVE-IT

John J.P. Kastelein, MD PhD FESC
ISA 2015 Chairman
Professor of Medicine, Dept. of Vascular Medicine, Academic Medical Center / University of Amsterdam
Amsterdam, The Netherlands