Increased acute CV risk 1 hour after moderate and heavy alcohol consumption
Alcohol and Immediate Risk of Cardiovascular Events: A Systematic Review and Dose-Response Meta-AnalysisLiterature - Mostofsky E, Chahal HS, Mukamal KJ, et al. - Circulation 2016; published online ahead of print
Moderate alcohol consumption was associated with
- a higher CV risk (approximately twofold) in the hour after alcohol intake
- a lower risk of MI and HS (2-4 drinks associated with 30% lower relative risk) after 24 hours
-a lower risk of IS after one week (6 drinks associated with 19% lower risk)
Heavy alcohol drinking was associated with
- a higher CV risk in the following day (6-9 drinks: RR: 1.3-2.3)
- a higher CV risk in the following week (19-30 drinks: RR: 2.25-6.2)
A U-shaped association was observed between the amount of alcohol intake within the 24 hours prior to MI onset and MI risk (pcurve<0.001) with
- the greatest benefit following approximately 28 grams of alcohol (2 drinks) in one day (RR: 0.67)
- a higher risk following approximately 108 grams (9 drinks) in one day (RR: 1.59).
When considering a week following alcohol consumption, a lower risk of MI was seen with moderate intake, and a higher risk after heavy alcohol consumption.
Similar U-shaped associations were observed for IS risk (pcurve=0.007) and for HS risk (pcurve=0.02).
Immediately following alcohol consumption, both harmful and protective physiologic responses take place. Moderate and heavy alcohol consumption was associated with a higher immediate CV risk in the hour after alcohol intake. After 24 hours, habitual moderate alcohol consumption was associated with a CV benefit, but heavy alcohol consumption was associated with continued CV risk.