test - SGLT2 inhibitor benefits younger, overweight, poorly controlled T2DM patients

Main results

• Adjusted mean change in HbA1c levels from baseline to week 24 of treatment with empagliflozin 10mg vs. placebo was −0.91% (95%CI: −1.11 to −0.71; P < 0.001) and with empagliflozin 25mg vs. placebo was −0.91% (95%CI: −1.12 to −0.70; P < 0.001).
• The percentage of participants with baseline HbA1c ≥ 64 mmol/mol (8%) achieving a value < 53 mmol/mol (7%) at 24 week was 23.8% vs. 3.6% for empagliflozin 10mg vs. placebo (OR: 8.69; 95% CI: 3.23-23.47; P<0.001) and 19.9% vs. 3.6% for empagliflozin 25mg vs. placebo (OR: 7.65; 95% CI: 2.77-21.11; P<0.001).

Adjusted mean change from baseline in body weight reduction at week 24 was −1.61 kg (95%CI: −2.16 to −1.05; P<0.001) for empagliflozin 10mg vs. placebo, and −1.81 kg (95% CI: −2.38 to −1.24; P<0.001) for empagliflozin 25mg vs. placebo.

• No statistically significant differences were seen between empagliflozin and placebo in changes in blood pressure at 24 weeks, with the exception of a lower diastolic blood pressure seen with empagliflozin 25mg vs. placebo (-2.0 mmHg, 95%CI: -3.6 to -0.4, P=0.015).
• Empagliflozin was well tolerated. Overall, adverse effects (AEs) were distributed similarly across treatment groups, except for a higher percentage of confirmed hypoglycaemia AEs with empagliflozin (5.6% and 5.0% for 10 and 25 mg respectively, vs. 3.6% with placebo) and genital infections (3.8% and 5.0% vs 1.4% with placebo).

Conclusion

References

Find this article online at J Diabetes Complications