Physicians' Academy for Cardiovascular Education

TMAO, formed by gut microbiota, associates with incident MACE and mortality

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

Literature - Li XS, Obeid S, Klingenberg R, et al. - Eur Heart J, 2017, Epub ahead of print

Main results


TMAO levels were associated with short-term risk of MACE and long-term mortality in two independent ACS cohorts comprising sequential patients who presented with complaint of chest pain and suspected ACS. The relationship with risk of incident MACE was dose-dependent. Therefore, gut microbiota-dependent metabolite, TMAO, may serve as a clinically useful and potentially modifiable prognostic marker.


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Find this article online at Eur Heart J

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