Physicians' Academy for Cardiovascular Education

Risk of heart failure increases with cardiac exposure radiotherapy in breast cancer patients

Risk of Heart Failure with Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer

Literature - Saiki H, Petersen IA, Scott CG, et al. - Circulation, 2017, [Epub ahead of print]

Main results


The odds of incident HF after radiotherapy increased with higher MCRD with predominantly HFpEF or HF with ‘mid-range’ (40-49%) EF and HF began within a few years after radiotherapy. Furthermore, these odds increased with MCRD, even after adjustment for other known risk factors and cancer stage. The current data also underscore the need to reduce MCRD, particularly in older women with HF risk factors, and the importance of techniques to reduce cardiac dose.


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Find this article online at Circulation

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