Physicians' Academy for Cardiovascular Education

Depression and exhaustion predict CVD mortality

Room for depressed and exhausted mood as a risk predictor for all cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men

Literature - Ladwig KH, Baumert J, Marten-Mittag B, et al. - Atherosclerosis 2017; published online ahead of print

Main results


DEEX predicts lower life expectancy and higher CVD mortality risk with an effect size comparable to traditional major risk factors. These findings underline the need for considering depression and exhaustion in a comprehensive screening and treatment strategy to prevent CVD, especially in subjects with an intermediate status of classical risk factors.


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