Physicians' Academy for Cardiovascular Education

Subspecies of HDL associated with anthropometrical measures and physical activity

Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III

Literature - Koch M, Furtado JD, Jiang GZ, et al. - J Lipid Res. 2017, Epub ahead of print

Main results


Several anthropometrical measures and physical activity strongly differentially associated with HDL subspecies, in which physical activity was the key factor. Regarding lifestyle, individuals with high alcohol consumption had higher levels of HDL without apoC-III. These factors are modifiable and it should therefore explored in intervention studies if an increase in physical activity differentially affects HDL subspecies via lowering abdominal obesity or by another mechanism. Furthermore, this study shows that beyond overall HDL, also protein composition of HDL might be relevant for the evaluation of primordial and primary prevention.


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