Classic risk factors at young age related to increased risk of recurrent cardiovascular events
Risk factors for recurrent cardiovascular events before age 65 or within 2.5 years of a recent first cardiovascular eventLiterature - Van de Berg MJ, Westerink J, Van der Graaf Y, et al. - Am J Cardiol 2017, In Press
- Current smoking (HR 1.43, 95% CI 1.11-1.84), diabetes (HR 1.83, 95% CI 1.32-1.54), high diastolic blood pressure (≥90 mmHg compared with 70-90 mmHg HR 1.54, 95% CI 1.15-2.07) and low HDL-c (≤ versus >1.0 HR 1.34, 95% CI 1.03-1.76) were related to increased risk of recurrent MACE in patients ≤65yrs. Analyses irrespective of age and sensitivity analyses showed comparable results.
- Current smoking (HR 1.65, 95% CI 1.23-2.22), physical inactivity (tertile 1 vs 3, HR 1.48, 95% CI 1.05-2.09), BMI (per kg/m2, HR 1.04, 95% CI 1.00-1.08), waist circumference (per 5 cm HR 1.11, 95% CI 1.05-1.18), diastolic blood pressure (>90 vs 70-90 mmHg HR 1.61, 95% CI 1.17-2.21), LDL-c (per 1 mmol/l HR 1.18, 95% CI 1.02-1.37) and non-HDL-c (per 1 mmol/L HR 1.15, 95% CI 1.03-1.28) were related to increased risk of recurrent MACE within 2.5 years of follow-up. HRs were comparable for risk of recurrent MACE with complete follow-up, except for diabetes and BMI.
In patients with a recurrent vascular event at a relatively young age and/or within a short time span, classical risk factors such as smoking, blood pressure and lipid levels are related to an increased risk of cardiovascular events.