Physicians' Academy for Cardiovascular Education

Sex differences in early dyspnea relief in the RELAX-AHF study

Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study

Literature - Meyer S, Teerlink JR, Metra M, et al. - Clin Res Cardiol. 2017;106(4):280-292


There are important gender-related differences regarding the onset of heart failure (HF), the features of established chronic HF, and the clinical characteristics at admission for acute HF [1,2]. Compared with men, women have more often hypertension, atriumfibrilleren, preserved left ventricle ejection fraction (LVEF), a longer length of hospitalization, and receive less diuretic medication, whereas men are more likely to have a history of myocardial infarction, reduced LVEF, and specific medical and device treatment [3,4].

In this analysis of the RELAX-AHF study [5,6], the gender differences in early and persistent dyspnea relief were investigated. Moreover, patient features and HF characteristics in men and women hospitalized for acute HF were analyzed.

Main results


In the RELAX-AHF study, women had better early dyspnea relief and improvement in general wellbeing compared with men, even after adjustment for age and LVEF. In-hospital and post-discharge clinical outcomes were similar between men and women.


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