Physicians' Academy for Cardiovascular Education

Evidence-based medications likely contributed to decreased rates of sudden death in heart failure

A meta-analysis showed that the rate of sudden death in HFrEF patients has fallen over the past two decades, suggesting a cumulative benefit of evidence-based medications on sudden death.

Shen L, Jhund PS, Petrie MC, et al. - N Engl J Med 2017; 377:41-51

Background

A meta-analysis showed that the rate of sudden death in HFrEF patients has fallen over the past two decades, suggesting a cumulative benefit of evidence-based medications on sudden death.

Main results

Conclusion

In a meta-analysis of 12 randomized trials, the rate of sudden death in HFrEF patients has fallen over the past two decades and the absolute rate of sudden death was lower among patients with a more recent diagnosis of HF. These findings suggest that there is a cumulative benefit of evidence-based medications on sudden death.

References

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