Physicians' Academy for Cardiovascular Education

NT–proBNP has additive predictive value for heart failure in diabetic patients

Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial

Literature - Ohkuma T, Jun M, Woodward M, et al; ADVANCE Collaborative Group. - Diabetes Care. 2017; published online ahead of print

Main results


In T2DM patients at high cardiovascular risk, markers IL-6, hs-CRP, hs-cTnT and NT-proBNP were independent predictors of the incidence of HF, but only the addition of NT-proBNP improved the predictive performance for HF on top of conventional clinical risk factors.


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