Physicians' Academy for Cardiovascular Education

Heart rate elevations over time predict a higher CV risk in HFpEF

Prognostic Importance of Temporal Changes in Resting Heart Rate in Heart Failure and Preserved Ejection Fraction - From the TOPCAT Study

Literature - Vazir A, Claggett B, Pitt B, et al. - J Am Coll Cardiol HF 2017; published online ahead of print

Main results


In patients with HFpEF, including those with AF, a higher baseline resting HR and time-updated HR, and an increase in resting HR over time from the preceding clinic visit were independently associated with an elevated risk for CV events. However, a decline in HR over time was not associated with a lower risk for CV events. These findings support the importance of measuring resting HR in everyday clinical practice, to identify HFpEF patients at higher risk for readmission and death.


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