Physicians' Academy for Cardiovascular Education

Hyperglycemia can explain cognitive dysfunction in diabetic patients

The Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance – The Maastricht Study

Literature - Geijselaers SLC, Sep SJS, Claessens D, et al. - Diabetes Care 2017; published online ahead of print

Main results


In participants of the Maastricht study, differences in cognitive performance between T2DM patients and NGM individuals, could be explained by hyperglycemia and partially by BP-related variables, particularly in the domains of processing speed and executive function plus attention, whereas IR has no mediating effects. These findings suggest that the prevention of diabetes-associated deterioration of cognitive performance should focus on early glycemic and BP control.


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Find this article online at Diabetes Care

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