Physicians' Academy for Cardiovascular Education

Sham-controlled PCI trial does not show symptom relief in stable angina patients

Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial

Literature - Al-Lamee R, Thompson D, Dehbi H-M, et al. - Lancet 2017; published online ahead of print

Main results


In this first blinded, placebo-controlled, randomized trial of PCI in 200 patients with stable angina and 1-vessel-disease (severe coronary stenosis, both anatomically and haemodynamically), PCI did not result in significant short-term improvements of exercise capacity, symptoms and quality of life as compared with a placebo procedure. PCI did yield objective relief of anatomical stenosis, invasive pressure and non-invasive perfusion indices. These data suggest that the physical effects of PCI may be overestimated and confused with placebo effects in clinical practice. These data suggest that PCI might not be essential for symptomatic improvement of these patients in the short-term.


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Find this article online at The Lancet

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