Physicians' Academy for Cardiovascular Education

Statin therapy associated with a lower risk of Parkinson’s Disease

Exploring the Association between Statin Use and the Risk of Parkinson’s Disease: A Meta-Analysis of Observational Studies

Literature - Poly TN, Islam M, Walther BA, et al. - Neuroepidemiology 2017;49:142–151

Main results


In a meta-analysis of 13 observational studies, statin use was associated with a modest reduction in the risk of developing Parkinson’s Disease compared with not using statins. When interpreting this result, the significant statistical and clinical heterogeneity among the included studies should be taken into account, as well as publication bias. No exact potential pathological hypothesis has been postulated that could explain how statin use may reduce the onset of PD. More experimental models are needed to help identifying a possible biological mechanism of these observations.


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