Physicians' Academy for Cardiovascular Education

Genetically determined dyslipidemia associated with abdominal aortic aneurysm

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm - A Meta-analysis

Literature - Harrison SC, Holmes MV, Burgess S, et al. - JAMA Cardiol 2017; published online ahead of print

Main results


In a meta-analysis of 5 GWASs, the genetic elevation of LDL-c and TG levels was associated with an increased risk of AAA, whereas increased HDL-c level was associated with a lower risk of AAA. These results suggest that patients with an AAA have a high burden of genetically determined dyslipidemia; appropriate treatment of this may lower their AAA risk.


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Find this article online at JAMA Cardiol

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