Physicians' Academy for Cardiovascular Education

Mendelian randomization studies can inform study design of RCTs, to set up naturally randomized trials

3' education - June 29, 2018 - Brian Ference, MD - Cambridge, UK

Brian Ference compares the design of Mendelian Randomization and RCTs and discusses how these types of studies can be combined to obtain more informative study results.

Educational information

In this video, Brian Ference explains how the study design of randomised clinical trials can benefit from information obtained in Mendelian Randomization studies. It aims to provoke thoughts on how RCTs can yield more informative results.


Brian Ference, MD is currently Clinical Chief of the Division of Cardiovascular Medicine, Director of the Cardiovascular Genomic Research Center, and Chief of the Division of Translational Research and Clinical Epidemiology at Wayne State University. His current research utilizes the principles of Mendelian randomization to identify risk factors that have both a causal and a cumulative effect of the risk of disease in an attempt to identify targets for early intervention, and to model “naturally randomized trials” that attempt to frame and answer clinical questions when an actual clinical trial would be impractical or impossible to conduct.


This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenters and do not necessarily reflect the views of PACE-cme.

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