Greatest risk reduction can be achieved in the highest risk groups

A principle that is true for many risk-lowering strategies, is that the relative risk reduction achieved with LDL-c lowering is similar across various subgroups with different risk levels. If the absolute risk is higher, however, the absolute risk reduction of lowering LDL-c is greater. Thus, the most aggressive treatment with PCSK9 inhibitors, which is also the most costly approach, should be targeted in the highest risk groups.

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