During this educational program, science, guidelines and daily practice of LDL lowering are disscussed in seven five-minute sessions by multiple experts.

This course consists of the following lectures:

• LDL-c as target in cardiology: the road towards lower targets - John Kastelein & Chris Packard
• Are very low LDL-c levels safe? - John Kastelein & Luis Masana
• Cholesterol guidelines in need of major changes? - Kausik Ray and François Mach
• What are the key issues and challenges impacting clinical management with novel therapeutics lowering cholesterol? - Kausik Ray and Gilles Montalescot
• Progressive CAD despite low LDL-c, an elusive disease? - Kausik Ray and Wouter Jukema
• How are the guidelines for progressive CAD guiding us in clinical practice? - John Kastelein and Ulf Landmesser
• Challenges for screening and treatment of FH patients in clinical cardiology - Kausik Ray and Kees Hovingh

After watching the videos on LDL-c and CV risk, the learner should be able to:

• Describe the biology and metabolism of LDL-c
• Explain whether achieving very low LDL-c levels in patients is safe
• Discuss how CV risk prediction can be improved
• Describe key issues and challenges that impact clinical management with cholesterol-lowering therapeutics
• Discuss whether progression of coronary artery disease (CAD) can be slowed down and if so, to what extent
• Summarize potential therapeutic approaches for the treatment of CAD
• Describe the challenges in and importance of screening for FH

Expert faculty

• Prof. John Kastelein - internist, Professor of Medicine, Department of Vascular Medicine at the Amsterdam University Medical Centers (AUMC), The Netherlands
• Prof. Chris Packard - Research and Development Director, NHS Greater Glasgow & Clyde Health Board; Honorary professor of vascular biochemistry, University of Glasgow, Scotland, UK
• Prof. Luis Masana - internist, University Rovira and Virgili, Reus-Tarragona, Spain
• Prof. Kausik Ray - cardiologist, Imperial College London, United Kingdom
• Prof. François Mach - cardiologist, University of Geneva, Switzerland
• Prof. Gilles Montalescot - cardiologist, Pitie-Salpetriere University Hospital, Paris, France
• Prof. Wouter Jukema - cardiologist, Leiden University Medical Center, Leiden, The Netherlands
• Prof. Ulf Landmesser - cardiologist, Charité-Universitätsmedizin Berlin, Germany
• Prof. Kees Hovingh - Internist and vascular medicine specialist at the Department of Vascular Medicine at the Academic Medical Center (AMC) of the University of Amsterdam

Target audience

This educational activity is designed for cardiologists in secondary care and other healthcare professionals with an interest in treating patients with cardiovascular disease.

CME accreditation

This online course is accredited by the European Board for Accreditation in Cardiology (EBAC) for 1 hour of external CME credit.

Through an agreement between the European Board for Accreditation in Cardiology and the American Medical Association, physicians may convert EBAC External CME credits to AMA PRA Category 1 Credits™. Information on the process to convert EBAC credit to AMA credit can be found on the AMA website. Other health care professionals may obtain from the AMA a certificate of having participated in an activity eligible for conversion of credit to AMA PRA Category 1 Credit™

Funding

Funding for this educational program was provided by an unrestricted educational grant from Amgen.