In this educational program lessons from the PARAGON-HF and other HF trials are discussed in three lectures.

This course consists of the following lectures:

• PARADIGM-HF and PARAGON-HF: Redefining HFrEF and HFpEF - Milton Packer, MD – Dallas, TX, USA
• Heart failure with mid-range ejection fraction - Prof. Burkert Pieske, MD – Berlin, Germany
• HFpEF: a misunderstood disease in search of a therapy - Prof. Scott Solomon, MD – Boston, MA, USA

After watching these four videos, the learner should be able to:

• Describe the function of neprilysin
• Reproduce outcomes of the PARADIGM-HF trial and the PARAGON-HF trial
• Recall up to which percentage ejection fraction benefit is observed with most studied HF drugs
• Know the definition of and therapeutic recommendations for HFmrEF
• Describe outcomes for HFmREF patients in the PARAGON-HF trial
• Recall outcomes of the preceding PARAMOUNT trial
• Describe findings of an analysis of pooled data from PARADIGM-HF and PARAGON-HF

Expert faculty

• Milton Packer, MD, is an internationally recognized clinical investigator in the field of heart failure. He spent most of this career in New York City, where he was the Dickinson Richards Professor and Chief of the Division of CIrculatory Physiology at Columbia University. From 2004-2015 he was Professor and Chair of the Department of Clinical Sciences at the University of Texas Southwestern Medical Center at Dallas. Dr. Packer is currently the Distinguished Scholar in Cardiovascular Science at Baylor University Medical Center, part of Baylor Scott & White Health.

• Prof. Burkert Pieske, MD, MD - is Director, Medical Department, Division of Cardiology Charité - University Medicine Berlin and Department of Internal Medicine - Cardiology, German Heart Institute, Berlin, Germany
• Prof. Scott Solomon, MD is Director Noninvasive Cardiology, Cardiovascular Medicine, Brigham and Women's Hospital and Professor at Harvard Medical School, Boston, MA, USA.

Target audience

This educational activity is designed for cardiologists in secondary care and other healthcare professionals with an interest in treating heart failure patients.

CME accreditation

This online course is accredited by the European Board for Accreditation in Cardiology (EBAC) for 1 hour of external CME credit.

Through an agreement between the European Board for Accreditation in Cardiology and the American Medical Association, physicians may convert EBAC External CME credits to AMA PRA Category 1 Credits™. Information on the process to convert EBAC credit to AMA credit can be found on the AMA website. Other health care professionals may obtain from the AMA a certificate of having participated in an activity eligible for conversion of credit to AMA PRA Category 1 Credit™.

Funding

Funding for this educational program was provided by an unrestricted educational grant from Novartis.