Physicians' Academy for Cardiovascular Education

Higher risk of mortality in hospitalized patients with COVID-19-associated cardiac injury

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Literature - Shi S, Qin M, Shen B et al. - JAMA Cardiol. 2020, doi: 10.1001/jamacardio.2020.0950.

Introduction and methods

It has been reported that 12% of COVID-19 patients had COVID-19-associated acute cardiac injury [1]. Cardiac implications of COVID-19 have also been addressed in the American Collage of Cardiology clinical bulletin [2]. However, the association between COVID-19-associated cardiac injury and mortality is unclear.

This retrospective single-center study explored the association between cardiac injury and mortality in COVID-19 patients in Wuhan, China. The total study population included 416 patients hospitalized with confirmed COVID-19. The median age was 64 years (21-95 years) and 50.7% were female. Cardiac injury was defined as high-sensitivity troponin I (hs-TNI) blood levels above the 99th-percentile upper reference limit, regardless of new abnormalities in electrocardiography and echocardiography. 82 patients (19.7%) had cardiac injury and 334 patients (80.3%) had no cardiac injury.

Patient characteristics, clinical laboratory, radiological, and treatment data were compared between COVID-19 patients with and without cardiac injury, and the association between cardiac injury and mortality was analyzed.

Main results


In this retrospective cohort study in Wuhan, China, cardiac injury occurred in 19.7% of hospitalized COVID-19 patients and these hospitalized COVID-19 patients with cardiac injury had a higher risk of in-hospital mortality compared to COVID-19 patients without cardiac injury.


Show references

Find this article online at JAMA Cardiol.

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