High consumption of sugary and light drinks associated with incident CVD
Sugary Drinks, Artificially-Sweetened Beverages, and Cardiovascular Disease in the NutriNet-Santé Cohort
Introduction and methods
Consumption of sugary drinks is associated with effects on cardio-metabolic outcomes and consumption is increasing worldwide [1,2]. A suggested healthier alternative are artificially sweetened beverages (ASB), but their cardiometabolic impact is under debate .
In the French NutriNet- Santé cohort, a large prospective cohort, the relationships between consumption of sugary drinks, ASB and risk of CVD was assessed.
In the French NutriNet- Santé cohort, participants are asked to fill out 3 validated web-based 24-h dietary records. ASB were defined as beverages containing non-nutritive sweeteners (NNS). Sugary drinks defined as all beverages containing ≥5% sugar (soft drinks, syrups, 100% juice, fruit drinks). Outcome of interest was first incident cases of stroke, transient ischemic attack, myocardial infarction, acute coronary syndrome and angioplasty. For each type of beverage intake, three categories were defined: nonconsumers, low consumers (median intake for sugary drinks: 46.7 mL/day and for ASB: 40.0 mL/day), and high consumers (median intake for sugary drinks: 185.0 mL/day and for ASB: 176.7 mL/day. Follow-up was from 2009 until 2019, with a median duration of 6.6. years. 104,760 Participants were included (mean age 42.9 years, 78.6% women).
- Mean daily intake of sugary drinks was 119.0 mL for men and 97.0 mL for women; and daily intake of ASB was 16.9 mL for men and 22.0 for women.
- Low consumers of sugary drinks and ASB had no increased risk of incident CVD compared to nonconsumers (adjHR 1.05, 95%CI: 0.92-1.20, and HR 1.15, 95%CI: 0.94-1.42, respectively)
- High consumers of sugary drinks and ASB had increased risk of first incident CVD compared to nonconsumers (adjHR 1.20, 95%CI: 1.04-1.40, Ptrend=0.009 and HR 1.32, 95%CI: 1.00-1.73, Ptrend=0.03).
In a large French cohort, high consumption of sugary drinks (median intake 185 mL/day) or ASB (median intake 176.7 mL/day) was associated with increased risk of incident CVD. These results suggest that ARB is not a healthy substitute for sugary drinks.