ACC 2020 Oral anticoagulant monotherapy reduced bleeding compared to anticoagulant therapy plus clopidogrel, without increasing ischemic events in AF patients undergoing TAVI.
ACC 2020 The POPular TAVI trial showed that OAC alone compared to OAC plus clopidogrel reduced bleeding and did not increase thrombotic events in AF patients undergoing TAVI.
This cluster randomized, non-inferiority trial showed that integrated care for elderly AF patients in a primary care setting led to a 45% reduction in all-cause mortality compared with usual care.
Although DOACs are safe and effective in AF patients, there are remaining challenges in prescribing DOACs. Freek Verheugt and John Eikelboom discuss 3 topics: underdosing, underuse and antidotes. With poll
The SGLT2 inhibitor dapagliflozin reduced time to first event of atrial fibrillation and atrial flutter as well as total events in T2DM patients, shown in a post-hoc analysis of the DECLARE-TIMI 58 trial.
The randomized ERADICATE-AF trial demonstrated that a combination of catheter ablation and renal denervation in patients with paroxysmal AF and hypertension resulted in higher likelihood of freedom from AF compared to catheter ablation alone.
The LOOP study used implanted loop recorders to detect previously unknown AF and determined AF burden, progression and symptoms in in elderly patients from the general population with CV risk factors.
In a real-world cohort including data of >60,000 AF ablation procedures performed between 2010-2015, early mortality rate was 0.46%. Strongest predictors for early mortality were procedural complications, CHF and low AF ablation hospital volume.
In a Danish cohort study of nonvalvular AF patients, DOAC use was associated with a lower risk of osteoporotic fractures compared to VKA treatment.
CSI Paris Tine Proesmans explains how screening for AF can be done in the general population using a smartphone and shares results of the DIGITAL-AF II study.
A meta-analysis of RE-DUAL PCI, PIONEER AF-PCI and AUGUSTUS compared NOAC- and VKA-based regimens and antithrombotic therapies with and without aspirin for ischemic outcomes and CV and total mortality.
Data of the Framingham Original and Offspring Cohorts show that parental smoking during childhood is associated with a higher AF risk, partly because offspring show higher propensity of smoking.