Physicians' Academy for Cardiovascular Education

HIV as a model to study effect of chronic inflammation on CV risk

Mar. 16, 2017 - VBWG ACC 2017

Lowering inflammation to address residual CV risk

Mar. 17, 2017 - Dr. Paul M. Ridker - Boston, MA, USA

Investigational epigenetic therapy lowers incidence of MACE in phase 2b study

Nov. 15, 2016 - AHA 2016, New Orleans, LA, USA - Dr. Norman Wong, Calgary, AB, Canada

Targeting residual inflammatory risk as a strategy to lower CV risk

Aug. 29, 2016 - ESC Rome, Italy - Prof. Paul Ridker (Boston, MA, USA)

Inflammation as potential target for therapy to target residual risk post ACS

Aug. 27, 2016 - ESC 2016, Rome - Paul M Ridker, MD – Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Understanding BET inhibition as a novel pathway for cardiovascular risk modulation

Aug. 28, 2016 - ESC 2016, Rome - Jorge Plutzky, MD – Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA - Recorded at PACE-CME symposium at ESC 2016

Inflammation, the immune system and atherosclerosis

July 7, 2015 - Amsterdam IAS

How to treat residual inflammatory risk?

Apr. 1, 2016 - VBWG Meeting at ACC 2016, Chicago, IL, USA - Paul Ridker, MD - Boston, MA, USA

Evolving hypotheses on the mechanisms underlying ACS

Apr. 1, 2016 - VBWG Meeting at ACC 2016, Chicago, IL, USA - Peter Libby, MD - Boston, MA, USA
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Attenuating inflammation by inhibition of p38 MAP-kinase does not reduce CV endpoints in LATITUDE TIMI-60

Apr. 11, 2016 - ACC 2016, Chicago, IL, USA - Michelle O'Donoghue

Changing views on mechanisms of atherosclerosis

Feb. 12, 2016 - Boston, MA, USA - Prof. Peter Libby (Boston, MA, USA)
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Inflammation and CV risk: Beyond statins in the treatment of atherosclerosis

Mar. 8, 2016 - Boston, MA, USA - Paul M Ridker

C-Reactive Protein, Inflammation and Atherosclerosis

Jan. 24, 2016
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Inflammation as target for therapy in atherothrombosis

Aug. 31, 2015 - ESC London - Prof Paul M Ridker
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Inflammation and Thrombosis

Sep. 29, 2015
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The changing character of atherosclerotic disease

May 24, 2015 - ISA2015, Amsterdam - Prof. Peter Libby

Cardiovascular Inflammation and Immunity in Atherosclerosis:

June 7, 2015 - Amsterdam
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Is inflammation reduction key for targeting residual risk, beyond lowering LDL-c?

Oct. 18, 2014 - Snapshot 2014 - Prof. Paul M Ridker, MD

Statin-loaded HDL nanoparticles

Jan. 23, 2014 - Raphaël Duivenvoorden - Raphaël Duivenvoorden
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Inflammation: targets for intervention

Oct. 3, 2013 - Snapshot 2013 - Ulf Landmesser

Inflammation & cardiovascular disease: Exploring new options for intervention

Sep. 30, 2013

Anti-PCSK9-vaccination has anti-atherogenic effects in mice

June 26, 2017 - news

Anti-PCSK9 vaccination (AT04A) lowers LDL-c, atherosclerosis and inflammatory markers in mouse model for atherosclerosis. Phase I study into this vaccine has started

Investigational IL-1β-blocker targeting inflammation meets primary endpoint in outcome study

June 22, 2017
Phase III CANTOS study shows IL-1β-blocker ACZ885 (canakinumab), in addition to standard care, reduces CV events in people with prior myocardial infarction and inflammatory atherosclerosis

The phase III CANTOS study shows ACZ885 (canakinumab), in addition to standard care, reduces CV events in people with prior myocardial infarction and inflammatory atherosclerosis.

Frequency and duration of tooth brushing is associated with endothelial function

June 19, 2017 - Matsui S et al. - Int J Cardiol 2017
High frequency and long duration of tooth brushing were associated with a better endothelial function, implying that adequate tooth brushing may contribute to the prevention of CV events.

High frequency and long duration of tooth brushing were associated with a better endothelial function, implying that adequate tooth brushing may contribute to the prevention of CV events.

BET inhibitor downregulates components of complement cascade

June 6, 2017 - Wasiak S, et al. - JCTR 2017

In addition to improving the lipoprotein and inflammatory profile, in vitro and in vivo experiments, as well as protein profiling of patient samples showed RVX-208 modulates the complement cascade.

HIV as a model to study effect of chronic inflammation on CV risk

Mar. 16, 2017 - VBWG ACC 2017
HIV-infected persons have increased CV risk. Even when HIV is adequately suppressed, chronic inflammation persists. Studying this condition can give insights in how to reduce CV risk and possibly HIV infection in these individuals.

VBWG ACC 2017 HIV-infected persons have increased CV risk. Even when HIV is adequately suppressed, chronic inflammation persists. Studying this condition can give insights in how to reduce CV risk and possibly HIV infection in these individuals.

New fully human PCSK9 antibody successful in phase 2 trial

(from the Phase 2 EQUATOR Study)

Apr. 26, 2017 - Baruch A, et al. - Am J Cardiol. 2017
RG7652, a fully human PCSK9 antibody, dose-dependently reduced LDL-c, ApoB and Lp(a), but not inflammatory proteins, without concerning adverse events in coronary heart disease patients

RG7652, a PCSK9 antibody, dose-dependently reduced LDL-c, ApoB and Lp(a), but not inflammatory proteins, without concerning adverse events.

Biomarker levels differ between HFpEF and HFrEF patients

Apr. 7, 2017 - Tromp J, et al. - JAHA 2017
Levels of biomarkers are different between patients with heart failure and reduced or preserved ejection fraction (HFrEF or HFpEF)

Biomarker levels, mainly those reflecting domains of cardiac stretch and inflammation, differ in HFpEF and HFrEF patients and possibly mirror different underlying pathophysiological processes.

Alcohol consumption associates with lower endothelial dysfunction and low-grade inflammation

Apr. 6, 2017 - Van Bussel BCT, et al. - Eur J Nutr 2017
Independent on fruit, vegetables, fish or dairy products, only consumption of alcohol and red wine were associated with lower endothelial dysfunction and low-grade inflammation in the Hoorn study.

Independent on fruit, vegetables, fish or dairy products, only consumption of alcohol and red wine were associated with lower endothelial dysfunction and low-grade inflammation in the Hoorn study.

Increased inflammatory activation in patients with familial dysbetalipoproteinaemia

Apr. 4, 2017 - Bernelot Moens SJ, et al. - Arterioscler Thromb Vasc Biol. 2017

Patients with familial dysbetalipoproteinaemia have increased arterial wall and cellular inflammation, as well as increased bone marrow activation.

Anti-inflammatory changes in response to PCSK9 antibody treatment in monocytes of FH patients

Feb. 20, 2017 - Bernelot Moens SJ et al., - Eur Heart J 2017

Circulating monocytes of FH patients not on statins showed a pro-inflammatory phenotype and intracellular lipid accumulation, which was reversed upon treatment with PCSK9 antibodies.

GLP-1 agonist lowers CV biomarkers in high-risk T2DM patients

Jan. 25, 2017 - von Scholten BJ, et al. - Diabetes Obes Metab. 2017

In T2DM patients with albuminuria, liraglutide treatment associates with reductions in circulating levels of CV risk biomarkers.

Amygdalar activity in response to stress predicts development of subsequent CV events

Jan. 19, 2017 - Tawakol A, et al., - The Lancet. 2017.

First study in humans to show a link between activity in the amygdala to subsequent CV events, likely via upregulation of haemopoietic tissue activity and increased atherosclerotic inflammation.