ISN-WCN 2019 Prof. David Cherney explains the major mechanisms underlying the protective effects of SGLT2 inhibition, followed by effects of SGLT2 inhibitors in non-diabetic kidney disease and future trials.
An analysis of the ADVANCE study shows that the treatment effect of perindopril-indapamide in patients with diabetes is independent of SBP, DBP or 10-year ASCVD risk at baseline.
No interaction was observed between diabetes status, guided DAPT de-escalation therapy vs. control therapy and outcomes in ACS patients after PCI.
ISN-WCN 2019 Use of canagliflozin in T2DM patients with kidney disease resulted in reduction of renal and CV outcomes, irrespective of baseline kidney dysfunction. Prof Carol Pollock discusses the results of the CREDENCE trial.
ISN-WCN 2019 Prof. Hiddo Lambers Heerspink dissusses the unique design of the SONAR trial and the findings with atrasentan therapy in patients with diabetic kidney disease.
In the PIONEER 3 trial, dosage of 7 and 14 mg oral semaglutide resulted in greater reductions of HbA1c compared to sitagliptin in T2DM patients.
ISN-WCN 2019 The SONAR trial was designed to safely test the effect of atrasentan in a selected group of high-risk T2DM patients with kidney disease. This proved to be a good approach, as results were very positive.
ICN-WCN 2019 Prof. Perkovic summarizes the results of the CREDENCE trial that tested the SGLT2 inhibitor canagliflozin. It is a safe drug that prevents kidney failure and CV complications in people with diabetes and kidney disease.
ISN-WCN 2019 In selected patients with T2DM and CKD, treatment with atrasentan significantly reduced the risk of the primary composite outcome of doubling of serum creatinine or end-stage kidney disease.
ISN-WCN 2019 In the CREDENCE study, patients with T2DM and CKD who were treated with canagliflozin had a lower risk of renal and CV outcomes than those randomized to placebo.
ONTARGET and TRANSCEND data show a non-linear association between mean achieved SBP and DBP and clinical outcomes, and event risk was higher in diabetes vs. no diabetes, across the BP spectrum
A subanalysis of the DECLARE TIMI-58 trial showed that use of dapagliflozin resulted in a greater reduction in MACE in T2DM patients with prior MI compared to those without MI.