Physicians' Academy for Cardiovascular Education

Herpes zoster enhances risk of stroke and myocardial infarction

July 11, 2017 - Kim M, et al. - JACC 2017

After rigorous adjustment for confounding factors, a propensity scoring analysis of a large Korean cohort revealed increased risk for stroke and myocardial infarction after herpes zoster infection.

Regular activity breaks improve postprandial triglyceride response

July 5, 2017 - Homer AR, et al. - J Clin Lipidol 2017

Measuring a full day after activity, a randomized crossover trial showed postprandial triglyceride response does improve by short breaks with activity, which is further increased by longer physical activity.

Obesity may be considered a distinct phenotype in heart failure with preserved EF

July 5, 2017 - Obokata M, et al. - Circulation. 2017

Obese patients with HFpEF have worse cardiovascular structure and function, more volume overload, and worse exercise capacity, compared with non-obese HFpEF patients.

Subcutaneous fat cell lipolysis independent contributor to variations in plasma lipids

July 5, 2017 - Rydén M and Arner P - ATVB 2017

In a large study cohort, high spontaneous lipolysis activity and resistance to antilipolytic effect by insulin was associated with high triglycerides and low HDL-c.

Extent of serum cholesterol-lowering associates with survival in homozygous FH

July 4, 2017 - Thompson GR, et al. - Eur Heart J 2017
A combined analysis showed that the extent of reduction of serum cholesterol achieved by a combination of therapeutic measures, is a significant determinant of survival in homozygous FH.

A combined analysis showed that the extent of reduction of serum cholesterol achieved by a combination of therapeutic measures, is a significant determinant of survival in homozygous FH.

Short time to furosemide treatment increases survival in acute heart failure

July 4, 2017 - Matsue Y, et al. - JACC 2017
In patients with acute HF, the early administration of furosemide - short door to furosemide (D2F) time = within 60 minutes of arrival at the emergency department - was independently associated with decreased in-hospital mortality.

In patients with acute HF, the early administration of furosemide - within 60 minutes of arrival at the emergency department - was independently associated with decreased in-hospital mortality.

Mutation-carrying relatives of patients with FH are at increased long-term CV risk

July 3, 2017 - Kjærgaard KA et al. - J Am Heart Assoc. 2017

Relatives of individuals with heterozygous familial hypercholesterolemia carrying LDLR mutations are at increased long-term risk of adverse CV events than non-carrier relatives and a general population cohort.

HFmrEF resembles HFrEF rather than HFpEF regarding IHD

June 28, 2017 - Vedin O, et al. - Circ Heart Fail. 2017

In the Swedish Heart Failure Registry, HFmrEF resembled HFrEF rather than HFpEF with respect to IHD as underlying cause, and IHD was a poor prognostic factor in all these 3 HF subtypes.

GLP-1 analogue approved by FDA for CV risk reduction in diabetes

June 28, 2017 - news

Based on the results of the LEADER trial, GLP-1 analogue liraglutide is approved by the FDA for CV risk reduction in type 2 diabetes

Worse survival when using lower than recommended doses of ACEi/ARBs or beta-blockers in heart failure

June 28, 2017 - Ouwerkerk W, et al. - Eur Heart J, 2017

In the BIOSTAT-CHF study, reaching less than 50% of the ESC guideline recommended dose of ACE-inhibitor/ARB or beta-blocker doses was associated with worse survival in HF patients.

CETP inhibitor meets primary endpoint in CV outcome study

June 27, 2017 - news

Treatment with anacetrapib, in addition to atorvastatin, reduced major coronary events in patients at risk for cardiac events in the REVEAL study.

Long-acting statins are also effective when taken in the morning

June 27, 2017 - Awad K, et al. - J Clin lipidol 2017

Short-acting statins are significantly more effective in lowering LDL-C and total cholesterol when taken in the evening, but long-acting statins are equally effective when taken in the morning and evening.