Physicians' Academy for Cardiovascular Education
Member

Emerging therapeutic areas in lipid management and CV disease

Mar. 16, 2017 - VBWG - ACC 2017 - Sotirios Tsimikas - La Jolla, CA, USA
Sotirios Tsimikas summarises the rationale of innovative therapeutic approaches targeting Lp(a), ApoC3 or ATP citric lyase and in what stage of clinical testing they currently are.

VBWG ACC 2017 Sotirios Tsimikas summarises the rationale of innovative therapeutic approaches targeting Lp(a), ApoC3 or ATP citric lyase and in what stage of clinical testing they currently are.

Disappointing results with therapy for acute heart failure

Apr. 30, 2017 - ESC HF 2017, Paris
At the ESC HF congress in Paris, professor Voors shares the disappointing results of the RELAX-AHF, in which treatment with serelaxin in acute HF did not result in improvement in mortality and worsening HF

ESC HF 2017 At the ESC HF congress in Paris, professor Voors shares the disappointing results of the RELAX-AHF, in which treatment with serelaxin in acute HF did not result in improvement in mortality and worsening HF

Different risk factors for stroke subtypes and depending on age

May 15, 2017 - Hauer AJ et al., - J Am Heart Assoc. 2017

Various stroke subtypes have different risk profiles particularly in younger individuals, supporting a more tailored primary and secondary stroke prevention strategy in younger patients.

John Cooke: Nanotherapeutic Solutions for Cardiovascular Disease

Mar. 16, 2017 - VBWG - ACC 2017

Long-term gluten consumption not associated with CHD risk in healthy individuals

May 15, 2017 - Lebwohl B et al. - BMJ 2017

In a large study, based on 4-yearly questionnaires during at least 20 years, gluten intake did not significantly affect the risk of CHD, but avoidance may increase the risk via reduced whole grain intake.

Initiating digoxin in AF patients associated with early hazard of sudden death

Mar. 19, 2017 - ACC 2017, Washington, DC, USA - Dr. Renato Lopes
A substudy of ARISTOTLE showed that new users of digoxin had a four-fold risk of sudden death, and higher plasma digoxin levels were associated with higher risk, also in AF patients who used digoxin at baseline.

ACC 2017 A substudy of ARISTOTLE showed that new users of digoxin had a four-fold risk of sudden death, and higher plasma digoxin levels were associated with higher risk, also in AF patients who used digoxin at baseline.

Significance and recommendations AF-screening

A Report of the AF-SCREEN International Collaboration

May 10, 2017 - Freedman B, et al. - Circulation 2017

Expert members of AF-SCREEN propose systematic or opportunistic screening approaches for AF based on known published data, to reduce the number of strokes and death.

The implications of PCSK9 outcome trials for GPs

Mar. 19, 2017 - Prof. Richard Hobbs – Oxford, United Kingdom - ACC 2017, Washington DC, USA
Prof. Richard Hobbs states that PCSK9 inhibition reduces endpoints that are important and expensive both for individuals and for health systems.

PCSK9 Expert Opinions Prof. Richard Hobbs states that recent data from FOURIER show that effective medical treatment to lower LDL-c reduces endpoints that are important and expensive both for individuals and for health systems.

Update on ACCF/AHA Heart Failure guidelines

A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America

May 10, 2017 - Yancy CW, et al. - Circulation 2017

This document updates the ACCF/AHA Heart Failure guidelines of 2013.

Insights in association plasma apo CIII levels with CAD risk

May 9, 2017 - Van Capelleveen JC, et al. - ATVB 2017

Strong association between elevated plasma apo CIII levels with CAD risk may be due to elevated levels of remnant lipoproteins, small dense LDL and low-grade inflammation.

Statin-related adverse events a nocebo effect?

May 9, 2017 - Gupta A, et al. - The Lancet 2017

In the ASCOT-LLA trial, adverse events, such as muscle pain, were associated with atorvastatin treatment in the unblinded phase, but not in de blinded phase of the trial

PCI-registry-based trial shows that IFR is non-inferior to FFR, with reduced discomfort and stenting

Mar. 20, 2017 - Matthias Götberg - Lund University, Sweden
Matthias Götberg summarises the advantages of the SCAAR-registry-based trial design of the randomised IFR-SWEDEHEART trial and shares the results of this study into clinical outcomes after IFR as compared with FFR.

ACC 2017 Matthias Götberg summarises the advantages of the registry-based trial design of the randomised IFR-SWEDEHEART trial and shares the results of this study into clinical outcomes after IFR as compared with FFR.

3' education

Which clinical PH groups can be distinguished?

May 22, 2017 - Bologna, Italy - Prof Nazzareno Galiè
Learn more about the clinical path of PAH!

Type of glycemic control is more important than tight glycemic control

May 1, 2017 - ESC HF 2017, Paris

Step forward in telemonitoring through use of an algorithm that risk-stratifies HF patients

May 31, 2017 - ESC HF 2017, Paris

Emerging therapeutic areas in lipid management and CV disease

Mar. 16, 2017 - VBWG - ACC 2017 - Sotirios Tsimikas - La Jolla, CA, USA

Disappointing results with therapy for acute heart failure

Apr. 30, 2017 - ESC HF 2017, Paris

John Cooke: Nanotherapeutic Solutions for Cardiovascular Disease

Mar. 16, 2017 - VBWG - ACC 2017

Initiating digoxin in AF patients associated with early hazard of sudden death

Mar. 19, 2017 - ACC 2017, Washington, DC, USA - Dr. Renato Lopes

PCI-registry-based trial shows that IFR is non-inferior to FFR, with reduced discomfort and stenting

Mar. 20, 2017 - Matthias Götberg - Lund University, Sweden

Factor Xa inhibitor vs. aspirin in extended phase of prevention recurrent VTE

Mar. 18, 2017 - ACC 2017, Washington, DC, USA - Dr. Philip S. Wells - Ottawa, ON, Canada

E-counselling improves adherence in hypertensives

Mar. 21, 2017 - Dr. Rob Nolan, Toronto, ONT, Canada

Troponin is an independent predictor of CV events at non-cardiac surgery

Mar. 21, 2017 - Dr. P.J. Devereaux - Hamilton, ONT, Canada

New diabetes treatments with CV benefit: A changing role for the cardiologist

Apr. 19, 2017 - Robert J Chilton, MD (San Antonio, TX, USA)

PCSK9 inhibitor safe for cognitive function, even at very low cholesterol levels

Mar. 19, 2017

Humanised PCSK9 antibody lowers CV events in high-risk patients, but LDL-c lowering effects decline over time

Mar. 17, 2017

CV outcomes with a PCSK9 inhibitor: FOURIER study

Mar. 16, 2017

Get involved in May Measurement Month!

Jan. 22, 2017 - London, United Kingdom - Prof. Neil R Poulter, MD (London, UK) - ISH President

Tailoring oral anticoagulation in elderly patients with AF

Nov. 12, 2016 - New Orleans, LA, USA - Christopher B. Granger, MD (Durham, NC, USA)

How low to go with blood pressure: J-curve or not?

Nov. 12, 2016 - New Orleans, LA, USA - Deepak L.Bhatt, MD, MPH (Boston, MA, USA)

Shifting priorities of care for older cardiac patients

Nov. 12, 2016 - New Orleans, LA, USA - Daniel E. Forman, MD (Pittsburgh, PA, USA)

HFpEF in older adults: TTR amyloid, under diagnosed and treatable?

Nov. 12, 2016 - New Orleans, LA, USA - Mathew S. Maurer, MD (New York, NY, USA)

Advancing CV care of cancer patients: Where are we now?

Nov. 12, 2016 - New Orleans, LA, USA - Javid J. Moslehi, MD (Nashville, TN, USA)

Modifying CV risk by managing diabetes

Nov. 12, 2016 - New Orleans, LA, USA - Jorge Plutzky, MD (Boston, MA, USA)

Blood pressure control in CKD in older people

Nov. 12, 2016 - New Orleans, LA, USA - Prof. George L Bakris, MD (Chicago, IL, USA)

Emerging therapies and treatment strategies in pulmonary arterial hypertension

Apr. 1, 2016 - VBWG Meeting at ACC 2016, Chicago, IL, USA - Paul R. Forfia, MD - Philadelphia, PA, USA

Pulmonary arterial hypertension (PAH) - video 1

Jan. 10, 2017 - Bologna, Italy - Nazzareno Galiè, MD
Learn more about the clinical path of pulmonary arterial hypertension!

Promising results in pivotal trials of novel lipid-modifying drugs

Dec. 12, 2016 - Amsterdam, The Netherlands - Prof. John JP Kastelein, MD (AMC Amsterdam, The Netherlands)

Investigational epigenetic therapy lowers incidence of MACE in phase 2b study

Nov. 15, 2016 - AHA 2016, New Orleans, LA, USA - Dr. Norman Wong, Calgary, AB, Canada

No clinical benefit of potent P2Y12 inhibitor over clopidogrel in peripheral artery disease

Jan. 4, 2017 - AHA 2016, New Orleans, LA, USA - Prof. Freek Verheugt, Amsterdam, The Netherlands

CAC reveals evidence of coronary artery calcification in third of low-risk women

Nov. 14, 2016 - AHA, New Orleans, LA, USA - Dr. Maryam Kavousi, Rotterdam, The Netherlands

Outstanding questions and ongoing studies on the use of NOACs

Oct. 7, 2016 - Berg en Dal, The Netherlands - Prof. Chris Granger, MD (Durham, NC, USA)

Lipid-lowering in the elderly - considering net benefit

Nov. 22, 2016 - AHA 2016 - Neil J. Stone, MD (Northwestern University Feinberg School of Medicine, Chicago, IL, USA)
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Peak VO2 maintained in HF patients on IV iron therapy

Nov. 22, 2016 - AHA 2016 - Dirk Jan van Veldhuisen, MD (UMC Groningen, The Netherlands)
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New class of lipid-lowering medication shows lasting LDL-c lowering in dose-finding study

Nov. 22, 2016 - Kausik Ray, MD - Imperial College London, United Kingdom
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Brief update on various pharmacotherapeutic strategies to lower CV risk

Nov. 21, 2016 - AHA 2016 - Prof. Wouter Jukema, MD (LUMC Leiden, The Netherlands)
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PCSK9 inhibitor on top of statin therapy gives additional atheroma volume regression

Nov. 21, 2016 - AHA 2016 - Steve Nissen, MD (Cleveland Clinic, Cleveland, OH, USA)
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Iron deficiency in the new HF guidelines

Aug. 29, 2016 - Peter van der Meer, MD - University Medical Center Groningen, The Netherlands
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Extra work of checking device data weekly does not translate into benefit for HF patient

Oct. 25, 2016 - ESC - 2016 Rome - Martin Cowie, MD - National Heart & Lung Institute, London, UK
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Customising therapy approach in ACS based on underlying pathology seems promising

Oct. 21, 2016 - ESC - 2016 Rome - Ik-Kyung Jang, MD - Massachusetts General Hospital, Boston, MA, USA
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No added value of monitoring platelet function after ACS

Oct. 6, 2016 - ESC - 2016 Rome - Stefan Gielen, MD - University of Leipzig, Germany

No indication for difference in efficacy between potent platelet inhibitors after PCI

Aug. 30, 2016 - ESC - 2016 Rome - Steen Dalby Kristensen, MD - Aarhus University, Denmark
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CPAP treatment of OSA neutral on CV endpoints but beneficial for quality of life

Oct. 4, 2016 - ESC - 2016 Rome - Prof Doug McEvoy, MD (Adelaide Institute for Sleep Health, Flinders University, Adelaide, Australia)
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Frequency apheresis lowered in FH patient receiving PCSK9-inhibiting treatment

Oct. 4, 2016 - ESC - 2016 Rome - Prof Patrick M Moriarty, MD (University of Kansas Medical Center, KS, USA)
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Mendelian randomisation study suggests that CV prevention could be simpler and more effective

Sep. 21, 2016 - ESC - 2016 Rome - Dr. Brian Ference (Detroit, MI, VS)
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Heart Failure news from ESC 2016 at a glance

Sep. 21, 2016 - ESC - 2016 Rome - Prof. Mariell Jessup (Philadelphia, PA, USA)
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The effect of treatment with DPP-4 inhibition on renal complications in diabetic patients.

Aug. 24, 2016 - Bangkok, Thailand - Prof. Per-Henrik Groop (University of Helsinki, Finland)
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A changing treatment paradigm in diabetes

July 30, 2016 - Bangkok, Thailand - Richard E. Pratley, MD (Florida Hospital Diabetes Institute, Orlando, FL, USA)
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SGLT2 inhibition in diabetic kidney disease

Aug. 24, 2016 - Bangkok, Thailand - Prof. Per-Henrik Groop (University of Helsinki, Finland)

New agents to treat hyperkalaemia

July 18, 2016 - ACC 2016 - Bertram Pitt, MD

Exciting times in diabetes treatment: new drug class moves beyond glucose reduction

Apr. 23, 2016 - Kuala Lumpur - Naveed Sattar - University of Glasgow, United Kingdom
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Novel small molecule that inhibits PAI-1 in development to slow vascular aging

Apr. 1, 2016 - VBWG Meeting at ACC 2016, Chicago, IL, USA - Douglas E. Vaughan, MD - Chicago, IL, USA

10' education

Changing therapeutic behaviour after FOURIER

Mar. 18, 2017 - Prof. Wolfgang Koenig - Munich, Germany - ACC 2017, Washington DC, USA

The implications of PCSK9 outcome trials for GPs

Mar. 19, 2017 - Prof. Richard Hobbs – Oxford, United Kingdom - ACC 2017, Washington DC, USA

PCSK9 inhibitors: From bench to bedside

Mar. 17, 2017 - Prof. Gilles Lambert – Sainte-Clotilde, France - ACC 2017, Washington DC, USA

The longer you treat, the better the benefit: lessons from PCSK9 inhibitors trials

Mar. 19, 2017 - Prof. Stephen J. Nicholls - Adelaide, Australia - ACC 2017, Washington DC, USA

Lowering LDL-c for a longer period of time really matters

Mar. 17, 2017 - Paul M. Ridker - Boston, MA, USA - ACC 2017, Washington DC, USA

No J-shaped curve for efficacy in PCSK9 outcome trials

Mar. 18, 2017 - Prof. Kausik Ray - London, United Kingdom - ACC 2017, Washington DC, USA

PCSK9 outcome trials: The results put into perspective of other clinical developments

Mar. 19, 2017 - Prof. Peter Sever - London, United Kingdom - ACC 2017, Washington DC, USA

LDL lowering for CVD prevention: From hypothesis to axiom

Mar. 19, 2017 - Prof. John JP Kastelein - Amsterdam, The Netherlands - ACC 2017, Washington DC, USA

Implications PCSK9 Outcome Trials: Should LDL-c targets in high-risk individuals be maintained or further lowered?

Mar. 18, 2017 - Prof. John Chapman - Paris, France - ACC 2017, Washington DC, USA

Careful implementation of PCSK9 inhibitors in clinical practice

Aug. 30, 2016 - ESC Rome, Italy - Prof. dr. Terje Pedersen (Oslo, Norway)

A minority of FH patients is identified and labeled as such, which impacts treatment

Aug. 29, 2016 - ESC Rome, Italy - Prof. Kausik Ray, MD (London, UK)

Possible approaches in precision medicine for secundary CV prevention

Aug. 30, 2016 - ESC Rome, Italy - Dr. Noel Bairey Merz (Los Angeles, CA, USA)

Would lower than the current ApoB targets be more useful for clinical decision-making?

Aug. 29, 2016 - ESC Rome, Italy - Seth Shay Martin, MD (Baltimore, MD, VS) and Allan Sniderman, MD (Montreal, Quebec, Canada).

Bisphosphonate as a potential new treatment for CV risk reduction

Aug. 27, 2016 - ESC, Rome, Italy - Guido Kranenberg (Utrecht, The Netherlands)

Oral anticoagulation in daily clinical practice in varous patient populations

Oct. 6, 2016 - The Netherlands - Prof. Chris Granger, MD (Durham, NC, USA) and Marc Brouwer, MD (Nijmegen, The Netherlands)

Understanding why patients do not take their medication and stimulating adherence

Aug. 27, 2016 - ESC Rome, Italy - Prof. Robert Horne (London, United Kingdom)

What can new glucose-lowering SGLT2-inhibitors add to CV risk management in diabetes?

Aug. 29, 2016 - ESC Rome, Italy - Prof. Silvio E Inzucchi (New Haven, CT, USA)

Interim results of new device for treatment resistant hypertension

Aug. 29, 2016 - ESC Rome, Italy - Dr. Wilko Spiering (Utrecht, The Netherlands)

Targeting residual inflammatory risk as a strategy to lower CV risk

Aug. 29, 2016 - ESC Rome, Italy - Prof. Paul Ridker (Boston, MA, USA)

Heart failure news at the ESC

Aug. 29, 2016 - ESC - 2016 Rome - Frank Ruschitzka, MD - University Heart Center, Zurich, Switzerland
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To SPRINT or not to SPRINT to a lower blood pressure target?

Aug. 29, 2016 - ESC Rome, Italy - William C Cushman (Memphis, TN, USA) and Sverre E Kjeldsen (Oslo, Norway)

Novel strategies targeting residual risk: The promise of PCSK9 inhibiting therapies

Aug. 28, 2016 - ESC 2016, Rome - Erik Stroes, MD – Academic Medical Center, Amsterdam, The Netherlands - PACE-CME symposium held at ESC 2016 in Rome

Beyond statins: The role of ezetimibe in targeting residual risk

Aug. 29, 2016 - ESC 2016, Rome - Chris Packard, MD – University of Glasgow, United Kingdom

Inflammation as potential target for therapy to target residual risk post ACS

Aug. 27, 2016 - ESC 2016, Rome - Paul M Ridker, MD – Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

A clinical perspective on PCSK9 inhibition: What do we know an what can we expect?

Aug. 27, 2016 - Paul M Ridker, MD – Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

PCSK9, the short track road from discovery as drug target towards the clinic

Aug. 27, 2016 - ESC 2016, Rome - Gilles Lambert, MD – Université de la Réunion, Sainte-Clotilde, France

Surviving elevated Lp(a): a patient story from diagnosis to treatment

May 27, 2016 - Innsbruck, Germany - Sandra Revill Tremulis, MBA - FRIDAY, MAY 27, 2016, lunch symposium at Lp(a) symposium prior to EAS

A patient with elevated Lp(a): What is current clinical practice to manage this condition?

May 27, 2016 - Innsbruck, Germany - Prof. Klaus G. Parhofer, MD - University of Munich, Germany - FRIDAY, MAY 27, 2016, lunch symposium at Lp(a) symposium prior to EAS

The future perspectives for care for patients with high Lp(a)

May 27, 2016 - Innsbruck, Germany - Prof. Erik Stroes, MD PhD – Academic Medical Center, Amsterdam, The Netherlands - FRIDAY, MAY 27, 2016, lunch symposium at Lp(a) symposium prior to EAS

HF & Diabetes: SGLT2 inhibition a paradigm shift?

Aug. 29, 2016 - ESC 2016, Rome, Italy - John McMurray, MD University of Glasgow United Kingdom - Recorded at PACE-CME symposium held during ESC 2016 in Rome

Challenging cardiovascular risk in diabetes: ready for a new approach?

Aug. 29, 2016 - John Deanfield, MD, University College London, United Kingdom

Overview of SGLT-2 inhibitors in T2DM management: current position & future promise

Aug. 29, 2016 - ESC, Rome Italy - Silvio Inzucchi, MD, Yale Diabetes Center, New Haven, CT, USA - PACE-CME symposium held at ESC 2016, Rome

Understanding BET inhibition as a novel pathway for cardiovascular risk modulation

Aug. 28, 2016 - ESC 2016, Rome - Jorge Plutzky, MD – Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA - Recorded at PACE-CME symposium at ESC 2016

BET inhibition in cardiovascular disease: A new dawn?

Aug. 28, 2016 - ESC 2016, Rome - John Kastelein, MD – Academic Medical Center, Amsterdam, The Netherlands - Recorded at PACE-CME symposium at ESC 2016

The high risk diabetes patient with cardiovascular disease: What else can we target to reduce cardiovascular risk?

Aug. 28, 2016 - ESC 2016, Rome - Kausik Ray, MD – Imperial College London, United Kingdom - Recorded at PACE-CME symposium at ESC 2016

Preparing for a novel era in CV prevention: Where do PCSK9 inhibitors fit in lipid management?

Aug. 27, 2016 - ESC 2016, Rome - John Kastelein, MD – Academic Medical Center, Amsterdam, The Netherlands

The future of HF management: How does potassium binding fit within pharmacological treatment of heart failure?

June 28, 2016 - ESC HF 2016, Florence, Italy - Kenneth Dickstein, MD - University of Bergen Stavanger University Hospital, Norway

Heart failure and SGLT2 inhibition: understanding the mechanism for potential benefit

May 21, 2016 - ESC HF 2016, Florence, Italië - Naveed Sattar, MD - Glasgow Universtiy, Glasgow, UK

Hyperkalemia: Novel treatment strategies to manage potassium levels in heart failure

May 23, 2016 - ESC HF 2016, Florence, Italy - Peter van der Meer, MD - UMCG Groningen, The Netherlands

RAAS inhibition in heart failure: Corner stone of therapy & potassium homeostasis

May 23, 2016 - ESC HF 2016, Florence, Italy - Faiez Zannad, MD - CHU- Nancy University Nancy, France

SGLT2 inhibition and cardiovascular outcomes: lessons from recent clinical trials

May 21, 2016 - ESC HF 2016, Florence, Italy - David Fitchett, MD - University of Toronto, ONT, Canada

Current treatment of Diabetes in Heart Failure

May 21, 2016 - ESC HF 2016, Florence, Italy - Adriaan Voors, MD - UMCG Groningen, The Netherlands

BP-lowering medication should not be used in normotensive primary prevention population at intermediate CV risk

May 10, 2016 - ACC 2016, Chicago, IL, USA - Eva Lonn (Hamilton, ONT, Canada)
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The spectrum of Heart Failure

May 11, 2016 - Boston, MA, USA - Dr. Marc Pfeffer
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What surprises have emerged from genetic studies of coronary artery disease?

Apr. 25, 2016 - Boston, MA, USA - Dr. Sekar Kathiresan (Boston, MA, USA)
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Diabetic dyslipidaemia and residual risk in the era of LDL control

Mar. 21, 2016 - Boston, MA, USA - Aruna Pradhan
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How will anti-PCSK9 therapy integrate into primary and secondary prevention of CVD?

Mar. 16, 2016 - Boston, MA, USA - Prof. Deepak Bhatt
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Changing views on mechanisms of atherosclerosis

Feb. 12, 2016 - Boston, MA, USA - Prof. Peter Libby (Boston, MA, USA)

HF Summit : innovation in clinical care in heart failure

Oct. 31, 2015 - Barcelona, Spain - Prof. Adriaan Voors and Prof. Martin Cowie
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A multidisciplinary approach in heart failure management

Oct. 31, 2015 - Barcelona, Spain - Aldo Maggioni, TIny Jaarsma, Richard Hobbs and Josep Comin-Colet
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