After rigorous adjustment for confounding factors, a propensity scoring analysis of a large Korean cohort revealed increased risk for stroke and myocardial infarction after herpes zoster infection.
Measuring a full day after activity, a randomized crossover trial showed postprandial triglyceride response does improve by short breaks with activity, which is further increased by longer physical activity.
Obese patients with HFpEF have worse cardiovascular structure and function, more volume overload, and worse exercise capacity, compared with non-obese HFpEF patients.
In a large study cohort, high spontaneous lipolysis activity and resistance to antilipolytic effect by insulin was associated with high triglycerides and low HDL-c.
A combined analysis showed that the extent of reduction of serum cholesterol achieved by a combination of therapeutic measures, is a significant determinant of survival in homozygous FH.
In patients with acute HF, the early administration of furosemide - within 60 minutes of arrival at the emergency department - was independently associated with decreased in-hospital mortality.
Relatives of individuals with heterozygous familial hypercholesterolemia carrying LDLR mutations are at increased long-term risk of adverse CV events than non-carrier relatives and a general population cohort.
In the Swedish Heart Failure Registry, HFmrEF resembled HFrEF rather than HFpEF with respect to IHD as underlying cause, and IHD was a poor prognostic factor in all these 3 HF subtypes.
Based on the results of the LEADER trial, GLP-1 analogue liraglutide is approved by the FDA for CV risk reduction in type 2 diabetes
In the BIOSTAT-CHF study, reaching less than 50% of the ESC guideline recommended dose of ACE-inhibitor/ARB or beta-blocker doses was associated with worse survival in HF patients.
Treatment with anacetrapib, in addition to atorvastatin, reduced major coronary events in patients at risk for cardiac events in the REVEAL study.
Short-acting statins are significantly more effective in lowering LDL-C and total cholesterol when taken in the evening, but long-acting statins are equally effective when taken in the morning and evening.