Physicians' Academy for Cardiovascular Education

PCSK9 inhibitors may represent the first therapeutic means to lower Lp(a)

3' education - June 29, 2018 - John Chapman - Paris, France
In high Lp(a)-associated CV risk patients, reduction of Lp(a) with PCSK9 inhibition lowered this risk, even at very low LDL-c levels.

In high Lp(a)-associated CV risk patients, reduction of Lp(a) with PCSK9 inhibition lowered this risk, even at very low LDL-c levels.

High prevalence of coronary microvascular dysfunction in patients with HFpEF

Literature - Sep. 10, 2018 - Shah SJ et al. - Eur Heart J 2018

Impaired coronary microvascular function is highly prevalent in HFpEF patients and is associated with high levels of natriuretic peptides, systemic endothelial dysfunction, and cardiac dysfunction.

Higher CV health associated with lower risk of dementia and cognitive decline in older adults

Literature - Sep. 6, 2018 - Samieri C et al. - JAMA 2018

An increase in number of optimal CV health metrics and higher CV health score were associated with reduced risk of dementia and lower rate of cognitive decline in older French individuals without CV disease.

THE GREAT DEBATE: Thrombocardiology post-COMPASS

ESC 2018 - Debates
ESC 2018 - Debates

ESC 2018 In one of this year’s organized debates, it was discussed how the COMPASS trial results should or should not change clinical practice; an impression of the arguments of both sides.

Harmful effects of alcohol and smoking on arterial system in adolescents

3' education - Sep. 4, 2018 - Marietta Charakida, MD - London, UK
In a subanalysis of the ALSPAC study, higher alcohol consumption and smoking were associated with increased arterial stiffness in teenagers. The good news is that the harmful effects of smoking seem reversible.

In a subanalysis of the ALSPAC study, higher alcohol consumption and smoking were associated with increased arterial stiffness in teenagers. The good news is that the harmful effects of smoking seem reversible.

Higher smoking exposure and alcohol consumption associated with increased arterial stiffness in adolescents

Literature - Sep. 4, 2018 - Charakida M, et al. - Eur Heart J 2018

A large cohort study demonstrated that higher drinking intensity and smoking exposure are individually and additively associated with increased arterial stiffness in adolescence.

PCSK9 inhibition results in consistent LDL-c lowering benefit in various patient subgroups

Literature - Sep. 4, 2018 - Stroes E et al. - Clin Cardiol 2018
In PROFICIO, a pooled analysis of four phase 3 trials showed significantly greater reductions in LDL-c with evolocumab vs placebo or ezetimibe for all demographic and disease status subgroups.

In PROFICIO, a pooled analysis of four phase 3 trials showed significantly greater reductions in LDL-c with evolocumab vs placebo or ezetimibe for all demographic and disease status subgroups.

EU’s EMA approves COMPASS regimen for prevention of CV events in high-risk CAD or PAD patients

News - Sep. 3, 2018

The combination therapy of low-dose rivaroxaban plus aspirin has received EMA approval for prevention of atherothrombotic events in adults with CAD or symptomatic PAD at high risk for ischemic events.

Combination pill with inhibitors of cholesterol synthesis and absorption met primary endpoint

News - Sep. 3, 2018

A bempedoic acid/ezetimibe combination pill safely lowered LDL-c and hsCRP, on top of maximally tolerated statin treatment in high-risk ASCVD patients, more than the individual components of the pill.

ARNI can be initiated early and safely in hospitalized patients after acute HF episode

News - Sep. 3, 2018

ESC 2018 The TRANSITION study results show that sacubitril/valsartan was safe and well-tolerated in a wide range of HFrEF patients who have been stabilized after an acute HF episode , showing CV safety.

Low-carbohydrate diets: increased risk of mortality in adults

ESC 2018 - Munich

News - Aug. 30, 2018

ESC 2018 The NHANES cohort study showed that low-carbohydrate diets increase the risk of mortality in adults, a finding that was validated by a meta-analysis of pooled prospective cohort studies.

Very high levels of HDL-c are associated with increased risk of CV events

ESC 2018 - Munich

News - Aug. 29, 2018

ESC 2018 In adults with CV disease, HDL-C levels >60 mg/dl (1.5 mmol/L) were associated with a nearly two-fold increase in the risk of CV death or MI.