In high Lp(a)-associated CV risk patients, reduction of Lp(a) with PCSK9 inhibition lowered this risk, even at very low LDL-c levels.
Impaired coronary microvascular function is highly prevalent in HFpEF patients and is associated with high levels of natriuretic peptides, systemic endothelial dysfunction, and cardiac dysfunction.
An increase in number of optimal CV health metrics and higher CV health score were associated with reduced risk of dementia and lower rate of cognitive decline in older French individuals without CV disease.
ESC 2018 In one of this year’s organized debates, it was discussed how the COMPASS trial results should or should not change clinical practice; an impression of the arguments of both sides.
In a subanalysis of the ALSPAC study, higher alcohol consumption and smoking were associated with increased arterial stiffness in teenagers. The good news is that the harmful effects of smoking seem reversible.
A large cohort study demonstrated that higher drinking intensity and smoking exposure are individually and additively associated with increased arterial stiffness in adolescence.
In PROFICIO, a pooled analysis of four phase 3 trials showed significantly greater reductions in LDL-c with evolocumab vs placebo or ezetimibe for all demographic and disease status subgroups.
The combination therapy of low-dose rivaroxaban plus aspirin has received EMA approval for prevention of atherothrombotic events in adults with CAD or symptomatic PAD at high risk for ischemic events.
A bempedoic acid/ezetimibe combination pill safely lowered LDL-c and hsCRP, on top of maximally tolerated statin treatment in high-risk ASCVD patients, more than the individual components of the pill.
ESC 2018 The TRANSITION study results show that sacubitril/valsartan was safe and well-tolerated in a wide range of HFrEF patients who have been stabilized after an acute HF episode , showing CV safety.
ESC 2018 The NHANES cohort study showed that low-carbohydrate diets increase the risk of mortality in adults, a finding that was validated by a meta-analysis of pooled prospective cohort studies.
ESC 2018 In adults with CV disease, HDL-C levels >60 mg/dl (1.5 mmol/L) were associated with a nearly two-fold increase in the risk of CV death or MI.