Physicians' Academy for Cardiovascular Education

Stroke

Summary | Changing focus in diabetes: From glucose to CV risk management

Munich, Berlin - August 27, 2018

This is a summary of the presentation by prof. Stephan Jacob, in which he talked about the management of diabetes, focusing on the shift from glucose to CV risk management in patients with diabetes.

Summary | SGLT2 inhibition in cardiology: What is the profile of benefit?

Munich, Berlin - August 27, 2018

This is a summary of the presentation by prof. Nikolaus Marx, in which he addressed the mode of action of SGLT2 inhibitors, and presented clinical outcome data and potential mechanisms.

For primary prevention, statins provide net benefits at higher than recommended 10-year risks

Literature - Dec. 17, 2018 - Yebyo HG et al. - Ann Intern Med 2018

In a quantitative modeling study, statins provided net benefit at higher 10-year risks for CVD than seen in most guidelines. The level of CVD risk at which net benefit occurs depends on age, sex, and statin type.

Type of existing CVD at baseline affects CV benefits of SGLT2 inhibition

Literature - Dec. 10, 2018 - Zelniker TA et al. - The Lancet 2018
A meta-analysis of three CVOTs showed moderate benefits of SGLT2i on atherosclerotic MACE only in those with ASCVD, whereas robust benefits on HHF and renal disease were observed regardless of baseline CVD or HF.

A meta-analysis of three CVOTs showed moderate benefits of SGLT2i on atherosclerotic MACE only in those with ASCVD, whereas robust benefits on HHF and renal disease were observed regardless of baseline CVD or HF.

DOAC treatment safe and effective in AF despite multi-morbidity

Literature - Dec. 4, 2018 - Alexander KP et al. - American Heart Journal 2018

A post-hoc analysis of the ARISTOTLE trial showed safety and efficacy of apixaban compared to warfarin in AF patients aged 55 years or older with multi-morbidity.

Long term benefits of antihypertensive and cholesterol-lowering treatment in hypertension

10' education - Nov. 20, 2018 - Dr. Ajay Gupta - London, UK
Dr. Ajay Gupta investigated the long term effects of treatment with a calcium channel blocker-based regimen and a statin on mortality in patients with hypertension, and showed a legacy effect of the combined therapy.

ESC 2018 Dr. Ajay Gupta investigated the long term effects of treatment with a calcium channel blocker-based regimen and a statin on mortality in patients with hypertension, and showed a legacy effect of the combined therapy.

GLP-1RA demonstrates CV safety and reduction in secondary mortality outcomes in T2DM

News - Nov. 26, 2018

The phase 3a PIONEER 6 trial met its primary endpoint, showing non-inferiority with regard to MACE, which was driven by a significant reduction in CV and all-cause mortality, compared to placebo, on top of standard care in T2DM.

More structural brain abnormalities discovered in prediabetes compared to no diabetes

Literature - Nov. 22, 2018 - Van Agtmaal MJM et al. - Diab Care 2018

Structural brain abnormalities are more common in patients with prediabetes compared with non-diabetics, and even more common in T2DM patients.

DPP-4 inhibitor non-inferior to placebo in preventing CV outcomes

Literature - Nov. 21, 2018 - Rosenstock J et al. - J Am Med Assoc 2018

In diabetic patients at high cardio-renal risk, linagliptin was non-inferior to placebo in preventing CV outcomes, but led to slightly more renal outcomes compared with placebo.

Antihypertensive treatment does not result in reduced mortality or CV events in low-risk patients with mild hypertension

Literature - Nov. 9, 2018 - Sheppard JP et al. - JAMA Intern Med 2018

In an observational study, antihypertensive treatment was not associated with reduced mortality or rates of CVD in low-risk patients with mild hypertension.

Higher healthy diet score is associated with a lower risk of mortality and CV events across the globe

3' education - Aug. 28, 2018 - Dr. Andrew Mente, Hamilton, ONT, Canada
In an analysis of four large global studies, higher healthy diet score was related to a lower risk of mortality, MI and stroke. Dr. Mente discusses how the healthy diet score is calculated and talks about the results of these four studies.

ESC 2018 In an analysis of four large global studies, higher healthy diet score was related to a lower risk of mortality, MI and stroke. Dr. Mente discusses how the healthy diet score is calculated and talks about the results of these four studies.

No overall benefit of use of aspirin in primary prevention setting in diabetes patients and individuals with moderate CV risk

ESC 2018 - Munich

News - Aug. 26, 2018

ESC 2018 One large randomized trial showed that use of aspirin for primary prevention reduced CV events in a diabetes population but at the cost of bleeding, and another resulted in no CV benefit in individuals with moderate CV risk.