Physicians' Academy for Cardiovascular Education

Initiation of SGLT2i therapy associated with decreased CV outcomes outside the US and Europe

Literature - June 14, 2018 - Kosiborod M, et al. - J Am Coll Cardiol 2018

In a pooled analysis of databases of 6 different countries, the initiation of SGLT2i was associated with lower risks of CV outcomes, as compared with other glucose-lowering drugs.

Obesity associated with high CV risk even in the absence of metabolic abnormalities

Literature - June 13, 2018 - Eckel N, et al. - Lancet Diab Endocrin 2018
CV risk is high in obese women without metabolic abnormalities, as well as in women with hypertension, diabetes or hypercholesterolemia, independently of their body mass index.

CV risk is high in obese women without metabolic abnormalities, as well as in women with hypertension, diabetes or hypercholesterolemia, independently of their body mass index.

Alcohol intake associated with higher risk of stroke subtypes and lower non-fatal CHD risk

Literature - June 11, 2018 - Ricci C, et al. - BMJ 2018

Both baseline and lifetime alcohol intake were inversely associated with the risk of non-fatal CHD, and positively associated with the risk of ischemic and hemorrhagic stroke.

CV risk remains high up to 5 years after TIA or minor stroke

Literature - May 31, 2018 - Amarenco P, et al. - New Engl J Med 2018
Patients with a transient ischemic attack or minor stroke had a sustained elevated risk of CV events up to 5 years after the first event, and approximately half of these events occurred after the first year.

Patients with a transient ischemic attack or minor stroke had a sustained elevated risk of CV events up to 5 years after the first event, and approximately half of these events occurred after the first year.

DPP-4 inhibitor is safe in post-ACS patients with T2DM, even in the high-risk period

Literature - May 29, 2018 - Sharma A, et al. - J Am Heart Assoc 2018
Compared with placebo, alogliptin did not increase CV risk in type 2 diabetic patients up to 6 months after an ACS, or later.

Compared with placebo, alogliptin did not increase CV risk in type 2 diabetic patients up to 6 months after an ACS, or later.

Factor Xa inhibitor shows lack of efficacy with increased bleeding in patients with embolic stroke of undetermined source

Literature - May 23, 2018 - Hart RG, et al. - N Engl J Med 2018

Rivaroxaban therapy is not beneficial for the prevention of stroke recurrence and associated with a higher risk of bleeding compared to aspirin in patients with embolic stroke of undetermined source.

EC approves PCSK9 inhibitor for patients with established atherosclerotic CVD

News - May 16, 2018

The European Commission (EC) has approved the use of evolocumab in patients with established atherosclerotic CVD (MI, stroke, PAD) to reduce CV risk.

GLP-1 analog reduces major CV outcomes in patients with atherosclerotic poly-vascular disease

Literature - May 16, 2018 - Verma S, et al. - Circulation 2018
Patients with T2DM and atherosclerotic poly-vascular disease have a higher CV risk than patients with single vascular disease, and in both groups liraglutide consistently reduced major CV outcomes.

Patients with T2DM and atherosclerotic poly-vascular disease have a higher CV risk than patients with single vascular disease, and in both groups liraglutide consistently reduced major CV outcomes.

Folic acid treatment reduces the risk of stroke in hypertensive patients

Literature - May 16, 2018 - Kong X et al. - J Am Coll Cardiol 2018
Patients with hypertension with low platelet counts and high total homocysteine levels, which may promote platelet adherence, had the highest risk of first stroke, and this risk was reduced with folic acid treatment.

Patients with hypertension with low platelet counts and high total homocysteine levels, which may promote platelet adherence, had the highest risk of first stroke, and this risk was reduced with folic acid treatment.

Pneumococcal and influenza infections associated with higher risk of CV events

Literature - Apr. 25, 2018 - Warren-Gash C, et al. - Eur Respir J 2018
Individuals with at least one laboratory-confirmed respiratory infection had a higher risk of MI or stroke, in particular when infected with S. pneumoniae or influenza virus.

Individuals with at least one laboratory-confirmed respiratory infection had a higher risk of MI or stroke, in particular when infected with S. pneumoniae or influenza virus.

Physical activity may modify high genetic risk for CVD

Literature - Apr. 23, 2018 - Tikkanen E, et al. - Circulation 2018

Different measures of fitness and physical activity were inversely associated with future CVD events and all-cause death, also in individuals with a high genetic CVD predisposition.

Alcohol consumption affects different CVD events in different ways

Literature - Apr. 16, 2018 - Wood AM et al., - The Lancet 2018

In a large prospective study, risk of all-cause mortality increases above 100 g alcohol per week, and positive associations with alcohol intake were seen mostly for stroke and HF, as opposed to MI.