In an analysis of two large U.S. cohorts, higher olive oil intake was associated with lower risk of major CVD and CHD risk compared to those consuming olive oil <1 per month.

Although DOACs are safe and effective in AF patients, there are remaining challenges in prescribing DOACs. Freek Verheugt and John Eikelboom discuss 3 topics: underdosing, underuse and antidotes. With poll

The phase III THALES trial with ticagrelor plus aspirin met the primary endpoint of stroke and death 30 days after acute ischemic stroke or TIA, but increased risk for bleeding, compared to aspirin alone.

This registry study showed that smoking before stroke onset increases the risk of poor functional outcome and functional dependence 3 months after acute ischemic stroke.

AHA 2019 The Treat Stroke to Target (TST) trial randomized patients with ischemic stroke or TIA with evidence of atherosclerosis to one of two LDL-c targets and found a benefit of the lower target.

A meta-analysis of 15 studies with more than 220,000 individuals showed that a mindset of optimism was associated with reduced risk of CV events and all-cause mortality.

ESC 2019 The THEMIS study evaluated the effect of ticagrelor vs. placebo on top of aspirin in diabetes patients with stable coronary artery disease. Netto clinical benefit depended on having a history of PCI or not.

In a large cohort study of 1.3 million participants, both systolic and diastolic hypertension were associated with composite of MI, ischemic stroke and hemorrhagic stroke, independent of thresholds defining hypertension.

In a meta-analysis of 21 RCTs including diverse populations, supplementation with vitamin D did not result in a reduction of MACE, MI, stroke/CVA, CV mortality and all-cause mortality compared to placebo.

ENGAGE AF-TIMI 48 data show that BMI was negatively associated with risk of stroke/SEE and positively associated with risk of bleeding, although sex differences were seen.

Dabigatran therapy did not result in a reduction of recurrent strokes compared to aspirin use after embolic stroke of undetermined source, whereas risk of nonmajor bleeding was higher with dabigatran.

A single-center prospective PCI-registry showed an independent association of high residual inflammatory risk and adverse clinical outcomes in patients undergoing PCI with LDL-c ≤70 mg/dL at baseline.