In a longitudinal 40-years follow-up, the impact of 8 traditional CV risk factors on CVD declined with aging, with the exception of LDL-c for MI, and BMI and fasting glucose for HF.
In a prospective community-based cohort, Lp(a) ≥50 mg/dL was associated with higher stroke risk in those without AF, but not in those with AF, nor with an elevated risk of AF.
In a large population-based cohort study, cholesterol variability was an independent predictor for the development of MI and stroke, as well as for all-cause mortality, in the general population.
AHA 2017 Laura Stevens presented her poster on using artificial intelligence to identify risk factors for CVD and stroke. The found association with coffee was validated with traditional analyses.
Stepwise higher concentrations of nonfasting triglycerides were associated with a stepwise higher risk of heart failure, which was not the case for LDL-c.
An analysis of the REVEAL AF study, demonstrated a substantial incidence of previously undiagnosed AF when insertable cardiac monitors were used for 18 to 30 months in patients at high risk for AF and stroke.
In the IMPROVE-IT study, the addition of ezetimibe to simvastatin in stabilized post-ACS patients reduced the frequency of ischemic stroke, particularly in patients with a history of prior stroke.
The discontinuation of statin therapy 3 to 6 months after an index ischemic stroke event, was associated with a higher risk of recurrent stroke within 1 year after statin discontinuation.
A large meta-analysis of nine studies confirmed association of PCSK9 loss-of-function variants with lower LDL-C levels and lower coronary heart disease risk, but not with stroke risk.
Complete data set from 503 patients show that idarucizumab led to immediate, complete and sustained reversal of the anticoagulant effect of dabigatran etexilate in emergency settings.
In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate.
After rigorous adjustment for confounding factors, a propensity scoring analysis of a large Korean cohort revealed increased risk for stroke and myocardial infarction after herpes zoster infection.