Physicians' Academy for Cardiovascular Education

Impact traditional CVD risk factors reduces as patients get older

Jan. 15, 2018 - Lind L et al. - J Am Heart Assoc. 2018

In a longitudinal 40-years follow-up, the impact of 8 traditional CV risk factors on CVD declined with aging, with the exception of LDL-c for MI, and BMI and fasting glucose for HF.

Differential associations seen between Lp(a) levels and stroke, depending on AF-status

Jan. 9, 2018 - Aronis KN et al., - J Am Heart Assoc. 2017

In a prospective community-based cohort, Lp(a) ≥50 mg/dL was associated with higher stroke risk in those without AF, but not in those with AF, nor with an elevated risk of AF.

Higher cholesterol variability associated with increased incidence of CV outcomes

Jan. 8, 2018 - Kim MK, et al. - Eur Heart J 2017

In a large population-based cohort study, cholesterol variability was an independent predictor for the development of MI and stroke, as well as for all-cause mortality, in the general population.

Machine learning program predicts that drinking more coffee lowers risk of CVD and stroke

AHA 2017 - Anaheim, CA, USA

Nov. 13, 2017 - AHA 2017 - Anaheim, CA - Laura M Stevens - Aurora, CO, USA
Laura Stevens presented her poster on using artificial intelligence to identify risk factors for CVD and stroke. The found association with coffee was validated with traditional analyses.

AHA 2017 Laura Stevens presented her poster on using artificial intelligence to identify risk factors for CVD and stroke. The found association with coffee was validated with traditional analyses.

Higher nonfasting triglycerides increase the risk of heart failure

Nov. 9, 2017 - Varbo A and Nordestgaard BG. - ATVB 2018

Stepwise higher concentrations of nonfasting triglycerides were associated with a stepwise higher risk of heart failure, which was not the case for LDL-c.

Long term cardiac monitoring with implanted device frequently reveals previously undiagnosed AF

Nov. 2, 2017 - Reiffel JA - JAMA Cardiology 2017

An analysis of the REVEAL AF study, demonstrated a substantial incidence of previously undiagnosed AF when insertable cardiac monitors were used for 18 to 30 months in patients at high risk for AF and stroke.

Cholesterol absorption inhibitor plus statin as secondary prevention protects against ischemic stroke

Oct. 5, 2017 - Bohula EA et al. - Circulation 2017

In the IMPROVE-IT study, the addition of ezetimibe to simvastatin in stabilized post-ACS patients reduced the frequency of ischemic stroke, particularly in patients with a history of prior stroke.

Higher risk of recurrent stroke after early statin discontinuation

Aug. 23, 2017 - Lee M et al. - J Am Heart Assoc. 2017

The discontinuation of statin therapy 3 to 6 months after an index ischemic stroke event, was associated with a higher risk of recurrent stroke within 1 year after statin discontinuation.

PCSK9 loss-of-function variants associate with lower LDL-C

Aug. 9, 2017 - Kent ST, et al. - Circ Cardiovasc Genet. 2017

A large meta-analysis of nine studies confirmed association of PCSK9 loss-of-function variants with lower LDL-C levels and lower coronary heart disease risk, but not with stroke risk.

Final phase III study results confirm benefit of NOAC reversal agent in emergency situations

July 17, 2017 - news

Complete data set from 503 patients show that idarucizumab led to immediate, complete and sustained reversal of the anticoagulant effect of dabigatran etexilate in emergency settings.

Mendelian randomization confirms association BMI and cardio-metabolic diseases

A Mendelian Randomization Study

July 14, 2017 - Lyall DM, et al. - JAMA Cardiology 2017

In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate.

Herpes zoster enhances risk of stroke and myocardial infarction

July 11, 2017 - Kim M, et al. - JACC 2017

After rigorous adjustment for confounding factors, a propensity scoring analysis of a large Korean cohort revealed increased risk for stroke and myocardial infarction after herpes zoster infection.