Physicians' Academy for Cardiovascular Education

Stroke

Updates in the 2020 AF guidelines

3' education - Sep. 2, 2020 - Prof. Isabelle van Gelder, MD
During the ESC Congress, the 2020 AF guidelines have been presented. Prof. Van Gelder gives an overview of the most important changes.

ESC 2020 During the ESC Congress, the 2020 AF guidelines have been presented. Prof. Van Gelder gives an overview of the most important changes.

Early rhythm control in AF patients improves outcomes

3' education - Aug. 29, 2020 - Prof. Paulus Kirchhof, MD
Prof. Kirchhof shares the findings of the EAST-AF NET 4 trial, which evaluated the effect of early rhythm control in patients who were recently diagnosed with AF compared to usual care.

ESC 2020 Prof. Kirchhof shares the findings of the EAST-AF NET 4 trial, which evaluated the effect of early rhythm control in patients who were recently diagnosed with AF compared to usual care.

Initiation of SGLT2i vs. DPP-4i associated with lower risk of CV events in T2DM

Literature - Aug. 18, 2020 - Kohsaka S et al., - Lancet Diabetes Endocrinol. 2020.

This comparative cohort study used data from clinical practice from 13 countries. Results showed that initiation of SGLT2i vs. DPP-4i in adults with T2DM was associated with lower risks of HF, death, MI and stroke.

HF development after T2DM diagnosis associated with highest 5-year risk of death

Literature - July 21, 2020 - Zareini B et al., - Circ Cardiovasc Qual Outcomes. 2020.

T2DM patients who developed HF alone or in combination with stroke, CKD or PAD had the highest 5-year risk of death and the greatest decrease in lifespan when compared with development of other CV and renal diseases.

P2Y12i plus aspirin reduces composite of recurrent stroke or death in stroke patients

Literature - July 20, 2020 - Johnston SC, et al. - N Engl J Med 2020

In the THALES trial, a combination of ticagrelor and aspirin reduced the composite endpoint of recurrent stroke or death in patients with stroke or TIA, but increased severe bleeding.

Similar risk of major bleeding with DOACs compared to VKAs in patients with NVAF

Literature - July 20, 2020 - Souverein PC et al., - Br J Clin Pharmacol. 2020.

This retrospective cohort study used longitudinal data from 4 European health care databases to compare the risk of major bleeding in DOAC and VKA users with nonvalvular atrial fibrillation (NVAF).

GLP-1RA might reduce cognitive impairment in T2DM

Literature - July 13, 2020 - Cukierman-Yaffe T, et al. - Lancet Neurol 2020

Treatment with the GLP-1RA dulaglutide for a median of 5.4 years resulted in a reduction of cognitive impairment compared to placebo in T2DM patients ≥50 years, in an exploratory analysis of REWIND.

No increased risk of stroke in AF patients without CV comorbidities

Literature - June 18, 2020 - Singleton MJ et al., - J Am Heart Assoc. 2020

This analysis of the REGARDS study showed that AF patients without CV comorbidities had no increased risk of stroke compared to individuals without AF or CV comorbidities.

Health professionals report decrease in STEMI admissions since COVID-19 outbreak

Literature - June 15, 2020 - Pessoa-Amorim G et al., - Eur Heart J Qual Care Clin Outcomes. 2020.

A survey conducted by the ESC among cardiologists and CV nurses revealed that 78.8% of responders perceived a decrease in STEMI admissions since the beginning of the COVID-19 outbreak.

P2Y12i monotherapy reduces risk of myocardial infarction compared to aspirin monotherapy

Literature - June 9, 2020 - Chiarito M et al., - The Lancet. 2020.

P2Y12i monotherapy reduces risk of MI, but not of stroke, all cause death, vascular death and bleeding, compared to aspirin monotherapy, in patients with established atherosclerosis.

Drinking filtered coffee associated with lower mortality

Literature - May 18, 2020 - Tverdal A et al., - Eur J Prev Cardiol. 2020.

A large Norwegian cohort study showed that drinking filtered coffee was associated with lower mortality than no coffee, while no association between coffee drinking and mortality was observed for those drinking unfiltered coffee.

AF associated with increased CV and total mortality in East Asian HFpEF patients

Literature - May 6, 2020 - Son MK, et al. - Heart. 2020

In a study of acute HF patients in a Korean registry, AF was more prevalent with increasing EF, and associated with increased CV and total mortality in HFpEF patients and increased risk of stroke in HFrEF and HFpEF patients.