Physicians' Academy for Cardiovascular Education

U shaped curve for association between sodium intake and CV events

Literature - Aug. 20, 2018 - Mente A et al. - The Lancet 2018

An analysis of a large population-based study showed that reduced sodium intake is associated with an increased CV risk and an increased sodium intake is associated with an increase in stroke.

Reduced risk of ischemic events but higher risk of hemorrhages with DAPT after ischemic stroke or TIA

Literature - July 25, 2018 - Johnston C, et al. - N Engl J Med 2018

In patients with minor ischemic stroke or high-risk TIA, treatment with clopidogrel and aspirin was associated with lower risk of major ischemic events, but higher risk of major and minor hemorrhages.

LDL-triglycerides associated with increased CVD risk

Literature - July 18, 2018 - Saeed A, et al. - JACC 2018

In a prospective study, LDL-TG levels were associated with an increased risk of CVD, including CHD and ischemic stroke. Lower LDL-TG levels were observed in individuals with the APOE ε2/2 haplotype.

Reduced CV risk with intensive blood pressure treatment in T2DM patients on standard glycemic control

Literature - July 11, 2018 - Tsujimoto T and Kajio H. - Hypertension. 2018
In a subanalysis of the ACCORD BP trial, intensive blood pressure treatment in T2DM patients receiving standard glycemic control was significantly associated with a decreased risk of CV events, including HF hospitalization.

In a subanalysis of the ACCORD BP trial, intensive blood pressure treatment in T2DM patients receiving standard glycemic control was significantly associated with a decreased risk of CV events, including HF hospitalization.

Healthy lifestyle after diabetes diagnosis reduces risk of CVD

Literature - July 3, 2018 - Liu G, et al. - J Am Coll Cardiol
Maintaining or changing to a healthy lifestyle after diabetes diagnosis is associated with a significantly lower risk CVD incidence and mortality.

Maintaining or changing to a healthy lifestyle after diabetes diagnosis is associated with a significantly lower risk CVD incidence and mortality.

Severe hypoglycemia associated with increased risk of CV events and mortality

Literature - June 19, 2018 - Zinman B, et al. - Diabetes Care 2018
In the LEADER trial, patients with severe hypoglycemia episodes had a higher risk of CV events and mortality compared with patients without severe hypoglycemia, independent of treatment group.

In the LEADER trial, patients with severe hypoglycemia episodes had a higher risk of CV events and mortality compared with patients without severe hypoglycemia, independent of treatment group.

Certain reproductive factors may increase future CV risk

Literature - June 18, 2018 - Peters SAE, and Woodward M. - Heart 2018

Several reproductive factors, including early menarche, a history of miscarriage or hysterectomy, earlier age at first birth, or an early menopause, were associated with an increased CV risk in later life.

Initiation of SGLT2i therapy associated with decreased CV outcomes outside the US and Europe

Literature - June 14, 2018 - Kosiborod M, et al. - J Am Coll Cardiol 2018

In a pooled analysis of databases of 6 different countries, the initiation of SGLT2i was associated with lower risks of CV outcomes, as compared with other glucose-lowering drugs.

Obesity associated with high CV risk even in the absence of metabolic abnormalities

Literature - June 13, 2018 - Eckel N, et al. - Lancet Diab Endocrin 2018
CV risk is high in obese women without metabolic abnormalities, as well as in women with hypertension, diabetes or hypercholesterolemia, independently of their body mass index.

CV risk is high in obese women without metabolic abnormalities, as well as in women with hypertension, diabetes or hypercholesterolemia, independently of their body mass index.

Alcohol intake associated with higher risk of stroke subtypes and lower non-fatal CHD risk

Literature - June 11, 2018 - Ricci C, et al. - BMJ 2018

Both baseline and lifetime alcohol intake were inversely associated with the risk of non-fatal CHD, and positively associated with the risk of ischemic and hemorrhagic stroke.

CV risk remains high up to 5 years after TIA or minor stroke

Literature - May 31, 2018 - Amarenco P, et al. - New Engl J Med 2018
Patients with a transient ischemic attack or minor stroke had a sustained elevated risk of CV events up to 5 years after the first event, and approximately half of these events occurred after the first year.

Patients with a transient ischemic attack or minor stroke had a sustained elevated risk of CV events up to 5 years after the first event, and approximately half of these events occurred after the first year.

DPP-4 inhibitor is safe in post-ACS patients with T2DM, even in the high-risk period

Literature - May 29, 2018 - Sharma A, et al. - J Am Heart Assoc 2018
Compared with placebo, alogliptin did not increase CV risk in type 2 diabetic patients up to 6 months after an ACS, or later.

Compared with placebo, alogliptin did not increase CV risk in type 2 diabetic patients up to 6 months after an ACS, or later.