Physicians' Academy for Cardiovascular Education

Physical activity may modify high genetic risk for CVD

Literature - Apr. 23, 2018 - Tikkanen E, et al. - Circulation 2018

Different measures of fitness and physical activity were inversely associated with future CVD events and all-cause death, also in individuals with a high genetic CVD predisposition.

Alcohol consumption affects different CVD events in different ways

Literature - Apr. 16, 2018 - Wood AM et al., - The Lancet 2018

In a large prospective study, risk of all-cause mortality increases above 100 g alcohol per week, and positive associations with alcohol intake were seen mostly for stroke and HF, as opposed to MI.

Continuous DOAC is safe and effective in patients with AF undergoing ablation

Literature - Apr. 16, 2018 - Kirchhof P, et al. - Eur Heart J 2018

In the AXAFA-AFNET 5 trial, continuous apixaban therapy was non-inferior to continuous VKA treatment in terms of stroke, bleedings, cognitive function and MRI-detected acute brain lesions.

Lipid level variability is predictive of cardiovascular events

Presented in part at the American Heart Association Annual Scientific Sessions, November 2017

Literature - Apr. 12, 2018 - Waters DD, et al. - J Clin Lipidol 2018

Visit-to-visit variability in fasting measurements of HDL-c, TG, and LDL-c is predictive of coronary events, CV events, and TG and LDL-c variability is also predictive of incident diabetes.

No association between familial hypercholesterolemia or high LDL-c levels and ischemic stroke risk

Literature - Apr. 4, 2018 - Beheshti S, et al. - Circulation 2018

Neither FH mutations, nor high LDL-c levels were associated with an increased risk of ischemic stroke, with the exception of patients with a history of ischemic heart disease.

Persons with atrial fibrillation at increased risk of dementia

Literature - Mar. 29, 2018 - Chen LY et al. - J Am Heart Assoc. 2018

Incident atrial fibrillation (AF) is associated with both greater cognitive decline and increased risk of dementia compared with individuals without AF, independent of clinical ischemic stroke.

Differential effect of LDL- and HDL-levels on small and large vessel disease and stroke type

Literature - Mar. 29, 2018 - Hindy G et al. - Stroke. 2018
Mendelian randomization study suggests that lowering LDL affects large artery atherosclerosis, but not small artery occlusion or cardioembolic stroke, while increasing HDL may benefit small artery disease.

Mendelian randomization study suggests that lowering LDL affects large artery atherosclerosis, but not small artery occlusion or cardioembolic stroke, while increasing HDL may benefit small artery disease.

Positive CHMP opinion for PCSK9 inhibitor to reduce CV risk in high-risk patients

News - Mar. 26, 2018

Following the results from the FOURIER trial, EMA’s CHMP has issued a positive opinion for the PCSK9 inhibitor evolocumab to reduce CV risk in patients with established ASCVD.

Prospective data of large real-world registry confirm safety profile of NOAC for stroke prevention in AF

News - Mar. 20, 2018

New data of the ongoing GLORIA-AF registry on use of dabigatran in AF show low rates of major bleeding and stroke, and long-term safety data are consistent with other real-world and RCT evidence.

IL-1β inhibitor reduces major vascular events in patients with CKD

Presented at ACC.18 by Paul Ridker (Boston, MA, USA)

News - Mar. 11, 2018
Treatment with canakinumab reduced MACE+ in patients with CKD in the CANTOS trial, with a stronger reduction in those who achieved on-treatment hsCRP<2 mg/mL compared to >2 mg/mL.

ACC 2018 Treatment with canakinumab reduced MACE+ in patients with CKD in the CANTOS trial, with a stronger reduction in those who achieved on-treatment hsCRP<2 mg/mL compared to >2 mg/mL.

Self-applied ECG patch improves the rate of AF diagnosis

Presented at ACC.18 by Steven Steinhubl (La Jolla, CA, USA)

News - Mar. 11, 2018

ACC 2018 In the digital mSToPS trial using patient-generated data, a wearable ECG patch improved the rate of AF diagnosis at 1 year compared to routine care.

New data challenge the obesity paradox with regard to CVD morbidity and longevity

Literature - Mar. 6, 2018 - Khan SS, et al. - JAMA Cardiol 2018
Overweight and obese individuals have a significantly increased long-term risk for CVD morbidity, and a similar or shorter total longevity, compared with individuals with a normal BMI.

Overweight and obese individuals have a significantly increased long-term risk for CVD morbidity, and a similar or shorter total longevity, compared with individuals with a normal BMI.