Kidney protection and SGLT2i: What do we know?

10' education - June 9, 2020 - Prof. Mark Cooper, MD - Monash University, Melbourne, Australia

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Epidemiology of CKD 00:32
Treatment options for DKD 02:23
Newer treatment options: GLP-1RAs and SGLT2 inhibitors 06:12
Ongoing SGLT2i trials enrolling CKD/DKD patients 11:18
EASD/ADA consensus report on choice of second-line therapy 12:07

Which statement is true about renal outcomes of recent SGLT2i trials?

A. Decline in eGFR was larger in macroalbuminuria patients on canagliflozin in CREDENCE
B. In EMPA-REG OUTCOME, patients with macroalbuminuria had renal benefit with empagliflozin
C. Use of SGLT2i in EMPA-REG OUTCOME, DECLARE-TIMI 58 and CANVAS resulted in CV benefit, but not renal benefit
D. A meta-analysis of four SGLT2i trials showed heterogeneity of renal outcomes with SGLT2i use

Educational information

This lecture by Mark Cooper was part of the EBAC-accredited symposium "Impacting cardiovascular and kidney protection in CKD: The evolving role of SGLT2i" held during the virtual ERA EDTA 2020 meeting.

Faculty

Prof. Mark Cooper, MD - Inaugural Head of the Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia.

Disclosures

This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme.

Funding

Funding for this educational program was provided by an unrestricted educational grant from Boehringer Ingelheim/Lilly.

View slides of the presentation