Physicians' Academy for Cardiovascular Education

HDL: moving forward after disappointing results with HDL-mimetic in CARAT study.

Mar. 19, 2017 - Prof. Stephen J. Nicholls - Adelaide, Australia

BET inhibition in renal and cardiovascular disease: What is the clinical roadmap?

June 5, 2017 - ERA-EDTA, Madrid Spain - Kamyar Kalantar-Zade, MD UC Irvine School of Medicine Irvine, Ca, USA

Molecular mechanisms involved in the beneficial effect of BET inhibition in experimental renal disease

June 5, 2017 - ERA-EDTA, Madrid Spain - Marta Ruiz-Ortega – Fundación Jiménez Díaz, Madrid, Spain

The high risk diabetes patient: What is the need for novel approaches to reduce cardiovascular and renal risk?

June 5, 2017 - ERA-EDTA, Madrid Spain - Luis M Ruilope, MD – Hospital 12 de Octubre, Madrid, Spain

UK: Clinical Dialogues: Lipids & Diabetes 2017

Dec. 7, 2017 - Stratford Upon Avon, United Kingdom - Prof Peter Sever

PCSK9 inhibition works, but you can’t force biology

Mar. 17, 2017 - Prof. Wouter Jukema – Leiden University Medical Center, The Netherlands - ACC 2017, Washington DC, USA

Identification of patients who will benefit is important after FOURIER

Mar. 19, 2017 - Prof. Ulf Landmesser - Charité - Universitätsmedizin Berlin, Germany - ACC 2017, Washington DC, USA

Landmark study with PCSK9 inhibitor will change clinical practice

Mar. 18, 2017 - Prof. Eric Bruckert - Pitié-Salpêtrière Hospital, Paris, France - ACC 2017, Washington DC, USA

Nanotherapeutic solutions to reduce atherosclerotic processes in the blood vessel

Mar. 16, 2017 - VBWG - ACC 2017 - John Cooke, MD, PhD - Houston, TX, USA

How incretin therapy changes diabetes and prediabetes management

May 22, 2017

HIV as a model to study effect of chronic inflammation on CV risk

Mar. 16, 2017 - VBWG ACC 2017

Lowering inflammation to address residual CV risk

Mar. 17, 2017 - Dr. Paul M. Ridker - Boston, MA, USA

Type of glycemic control is more important than tight glycemic control

May 1, 2017 - ESC HF 2017, Paris

Changing therapeutic behaviour after FOURIER

Mar. 18, 2017 - Prof. Wolfgang Koenig - Munich, Germany - ACC 2017, Washington DC, USA

Step forward in telemonitoring through use of an algorithm that risk-stratifies HF patients

May 31, 2017 - ESC HF 2017, Paris

Emerging therapeutic areas in lipid management and CV disease

Mar. 16, 2017 - VBWG - ACC 2017 - Sotirios Tsimikas - La Jolla, CA, USA

Disappointing results with therapy for acute heart failure

Apr. 30, 2017 - ESC HF 2017, Paris

Initiating digoxin in AF patients associated with early hazard of sudden death

Mar. 19, 2017 - ACC 2017, Washington, DC, USA - Dr. Renato Lopes

Challenges in Heart Failure management: Diabetes and Renal Impairment

May 12, 2017 - Paris, France - Martin Cowie, MD - ESC Heart Failure, Paris

The implications of PCSK9 outcome trials for GPs

Mar. 19, 2017 - Prof. Richard Hobbs – Oxford, United Kingdom - ACC 2017, Washington DC, USA

Long working hours associated with an increased risk for atrial fibrillation

July 20, 2017 - Kivimäki M et al. - Eur Heart J 2017;

In a large-scale meta-analysis, participants working over 55 h/week were 40% more likely to develop AF compared with those working standard hours, independently of known AF risk factors.

High levels of gut microbiome-generated TMAO associated with CV events and mortality

July 19, 2017 - Schiattarella GG et al. - Eur Heart J 2017

First systematic review and dose-response meta-analysis shows dose-dependent association between high TMAO levels and increased risk of MACCE and all-cause mortality in large CVD population.

Single 24-hour urine collection does not suffice to estimate an individual’s sodium intake

July 19, 2017 - Olde Engberink RHG et al., - Circulation. 2017

Multiple 24-hour urine collections are needed for reliable estimation of individual sodium intake and the associated CV and renal risk. Single measurement suffices for population estimates.

Iron supplementation maintains exercise capacity in heart failure with iron deficiency

July 19, 2017 - van Veldhuisen DJ et al. - Circulation. 2017

In patients with chronic HF and iron deficiency, IV iron supplementation has a beneficial effect on peak VO2 compared to standard of care, irrespective of the presence of baseline anemia.

CAC occurs more often in most active athletics, but with a more beneficial plaque composition

July 18, 2017 - Aengevaeren VL, et al. - Circulation. 2017

Athletics with >2000 MET-min/week had a higher prevalence of CAC and atherosclerotic plaques, but these were more often calcified rather than mixed plaques.

Quarter-dose combinations BP-lowering medications improve management hypertension

A Systematic Review and Meta-Analysis of Randomized Controlled Trials

July 18, 2017 - Bennett A, et al. - Hypertension. 2017

In a meta-analysis, dual quarter-dose combinations of BP-lowering agents were as effective as standard-dose monotherapy, whereas a quadruple quarter-dose combination was twice as efficacious.

Lipid transfer to HDL and HDL-c levels impaired in long-term bedridden patients

July 17, 2017 - de Oliveira WPC et al., - Lipids. 2017

LDL-c and triglyceride levels were well-controlled in bedridden patients, but HDL-c levels were low as compared with sedentary subjects, which affected lipid transfer to HDL.

Final phase III study results confirm benefit of NOAC reversal agent in emergency situations

July 17, 2017 - news

Complete data set from 503 patients show that idarucizumab led to immediate, complete and sustained reversal of the anticoagulant effect of dabigatran etexilate in emergency settings.

Mendelian randomization confirms association BMI and cardio-metabolic diseases

A Mendelian Randomization Study

July 14, 2017 - Lyall DM, et al. - JAMA Cardiology 2017

In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate.

NT–proBNP has additive predictive value for heart failure in diabetic patients

July 12, 2017 - Ohkuma T, et al. - Diabetes Care. 2017

In diabetic patients at high cardiovascular risk, markers IL-6, hs-CRP, hs-cTnT and NT-proBNP were independent predictors of heart failure, while NT-proBNP also had an additive predictive value.

Evidence-based medications likely contributed to decreased rates of sudden death in heart failure

July 12, 2017 - Shen L, et al. - N Engl J Med 2017

A meta-analysis showed that the rate of sudden death in HFrEF patients has fallen over the past two decades, suggesting a cumulative benefit of evidence-based medications on sudden death.

Breastfeeding reduced CHD risk in Chinese parous women

July 12, 2017 - Peters S.A.E, et al. - J Am Heart Assoc 2017

In China, where breastfeeding practice is almost universal across the country, parous women who had ever breastfed had a lower risk of CHD compared to parous women who never breastfed.