COMPASS-eligible patients represented a substantial fraction of the spectrum of stable CAD and PAD outpatients from the REACH registry.
In a sub-analysis of the ARIC study, midlife systemic inflammation was associated with the development of chronic microangiopathic structural white matter abnormalities in the elderly.
Notably, new recommendations in the 2018 edition of the ADA Standards of Care reflect advances in diabetes treatment with antidiabetic drugs with CV benefit.
Based on the results of the SUSTAIN trial, semaglutide is approved by the FDA for the treatment of T2DM patients.
The DIRECT trial evaluated a weight management program delivered by primary care. On average, weight reduced by 10 kg and almost half achieved and maintained remission of T2DM at 12 months after starting the intervention.
In heart failure patients with a reduced EF, paroxysmal AF and new onset AF were associated with a greater risk of adverse outcomes, including HF hospitalization and stroke, but not mortality.
Genetically determined elevation of LDL-c and TG levels was associated with an increased risk of abdominal aortic aneurysm, whereas elevated HDL-c level was associated with a lower risk thereof.
Mendelian randomisation suggests that CETP is not causally related to atherosclerosis in the general population, but only in men with normal glucose, HDL, and TG levels, and in women with ¬¬high CV risk or abnormal fasting glucose.
Following FDA Priority Review, evolocumab is the only PCSK9 inhibitor approved to reduce risk of myocardial infarction, stroke and coronary revascularization in adults with established CVD.
KardiaBand evaluates heart rate and physical activity, and instantly pushes notifications to take an EKG, which can be recorded in 30 second with its integrated sensor.
Patients with a history of MI have a higher risk of vascular dementia, particularly if they additionally have a history of stroke, probably due to common risk factors for both diseases.
In an analysis of the TITRATION study, the majority of patients with low screening SBP tolerated the initiation/up-titration to target dose level of sacubitril/valsartan using a gradual up-titration regimen.