In a large-scale meta-analysis, participants working over 55 h/week were 40% more likely to develop AF compared with those working standard hours, independently of known AF risk factors.

First systematic review and dose-response meta-analysis shows dose-dependent association between high TMAO levels and increased risk of MACCE and all-cause mortality in large CVD population.

Multiple 24-hour urine collections are needed for reliable estimation of individual sodium intake and the associated CV and renal risk. Single measurement suffices for population estimates.

In patients with chronic HF and iron deficiency, IV iron supplementation has a beneficial effect on peak VO2 compared to standard of care, irrespective of the presence of baseline anemia.

Athletics with >2000 MET-min/week had a higher prevalence of CAC and atherosclerotic plaques, but these were more often calcified rather than mixed plaques.

In a meta-analysis, dual quarter-dose combinations of BP-lowering agents were as effective as standard-dose monotherapy, whereas a quadruple quarter-dose combination was twice as efficacious.

LDL-c and triglyceride levels were well-controlled in bedridden patients, but HDL-c levels were low as compared with sedentary subjects, which affected lipid transfer to HDL.

Complete data set from 503 patients show that idarucizumab led to immediate, complete and sustained reversal of the anticoagulant effect of dabigatran etexilate in emergency settings.

In a large population-based cohort study, BMI was associated with risk of hypertension, CHD, T2DM, elevated SBP and DBP based on causal mendelian randomization estimates, but not with stroke or pulse rate.

In diabetic patients at high cardiovascular risk, markers IL-6, hs-CRP, hs-cTnT and NT-proBNP were independent predictors of heart failure, while NT-proBNP also had an additive predictive value.

A meta-analysis showed that the rate of sudden death in HFrEF patients has fallen over the past two decades, suggesting a cumulative benefit of evidence-based medications on sudden death.

In China, where breastfeeding practice is almost universal across the country, parous women who had ever breastfed had a lower risk of CHD compared to parous women who never breastfed.