Prof. Ray explains how he decides on the amount of LDL-c lowering that is needed in a given patient, and why he chooses this approach.
The SGLT2 inhibitor dapagliflozin reduced time to first event of atrial fibrillation and atrial flutter as well as total events in T2DM patients, shown in a post-hoc analysis of the DECLARE-TIMI 58 trial.
Higher intake of processed meat, unprocessed red meat or poultry was associated with a small increased risk of incident CVD. For all-cause mortality, a small increased risk was observed with higher intake of processed meat or unprocessed red meat.
Which lipids/lipoproteins, besides LDL-c, play a role in determining CV risk and can help targeting therapy in those with residual lipid risk?
This retrospective observational study using heart rate (HR) data from wearable devices found that average resting HR varies widely between individuals, but is more consistent over time within individuals.
The open-label TAUSSIG study evaluated treatment with evolocumab during a median follow-up of 4.1 years and found a similar safety profile and good LDL-c lowering in HoFH and HeFH patients
Prof. Bhatt gives an in-depth overview of the REDUCE-IT trial, in which the effect of icosapent ethyl, a highly purified form of EPA, on CV outcomes was studied. WIth question to test your knowledge.
This subanalysis of the ACCELERATE trial showed that HbA1c levels at study baseline are associated with CV outcomes in T2DM patients with a history of coronary artery disease and on optimal medical therapy.
Adults who started primary CV preventive pharmacotherapy showed higher BMI and more inactivity, but reduced smoking and alcohol consumption after about 4 years than those not taking drugs.
An analysis of data of the dal-OUTCOMES trial shows that concentration of HDL particles is not associated with risk of MACE in patients after ACS.
Prof. Cannon presents clinical studies demonstrating that lower LDL-c with use of statins and ezetimibe decreases CV risk. Unfortunately, studies using registries show that these agents are often not used.
This study evaluated a community-based screening approach in 8 barbershops in Brooklyn, New York and found a prevalence of undiagnosed diabetes in 9.0% of the black male participants.