Physicians' Academy for Cardiovascular Education

Novel small molecule that inhibits PAI-1 in development to slow vascular aging

3' education - Apr. 1, 2016 - VBWG Meeting at ACC 2016, Chicago, IL, USA - Douglas E. Vaughan, MD - Northwestern University of Michigan, Chicago, IL, USA

An investigational inhibitor of plasminogen activator inhibitor type 1 (PAI-1) prevented arteriosclerosis in mice and prolonged life in mice with a rapid aging phenotype. As elevated PAI-1 may play a role in intravascular thrombosis, and since it is a marker of cellular senescence, the inhibitor is being developed to treat or slow down vascular aging. Phase 2 studies are being planned after phase I studies showed no sign of apparent toxicity.

Educational information

Vascular Biology Working Group Meeting at ACC 2016, Chicago, IL, USA


Douglas E. Vaughan, MD - Chair of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

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