Physicians' Academy for Cardiovascular Education

Understanding BET inhibition as a novel pathway for cardiovascular risk modulation

10' education - Aug. 28, 2016 - ESC 2016, Rome - Jorge Plutzky, MD – Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA - Recorded at PACE-CME symposium at ESC 2016

This lecture was part of a CME accredited symposium: 'A novel approach for high CV risk patients with diabetes: The potential of epigenetics' held at ESC 2016 in Rome

Video navigation menu

  • Concept of coordinated programs in cardiometabolic states by key proximal transcription factors 00:40
  • Epigenetics as a way of regulating these programs above the level of the DNA 03:40
  • The role of epigenetics in diabetes 06:53
  • Current issues in epigenetics/BETs: Super enhancers 09:30
  • Endothelial effects of BET inhibition 10:47
  • Association of BRD4 with many pro-inflammatory, pro-atherosclerotic target genes 14:28
  • Apabetalone reduces atheroma in aorta of apo E-/- mice 15:52

Educational information

The educational objectives of this symposium were:

CME accreditation

This programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for 1 hour of external CME credit(s).


Jorge Plutzky, M.D. is the Director of the Vascular Disease Prevention Program, which includes the Lipid/Prevention Clinic, at Brigham and Women’s Hospital (BWH), and is on the faculty of Harvard Medical School


Supported by an unrestricted educational grant from Resverlogix