Beyond statins: The role of ezetimibe in targeting residual risk
This lecture was part of a CME accredited symposium: How to address residual risk post ACS: LDL-c, dyslipidemia, and inflammation held at ESC 2016 in Rome
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Impact of dual inhibition of cholesterol synthesis and absorption 01:27
IMPROVE-IT: results of ezetimibe on top of statin 02:47
Clinical evidence for LDL lowering supported by genetic studies 03:56
Long-term benefits of LDL-lowering: WOSCOPS 20-year follow-up 06:07
Options for optimal LDL/non HDL-C lowering 10:53
Summary 11:30
Educational information
The educational objectives of this symposum were to:
- Discuss the potential of current and future strategies targeting inflammation in reducing residual risk in post ACS patients
- Outline current ongoing clinical development programs aimed at testing the inflammation hypothesis of cardiovascular disease
- Understand the unmet need for additional LDL-C-lowering therapies beyond current optimal statin-based therapy as a strategy for addressing lipid-related CV risk in patients post ACS
- Describe the potential impact of PCSK9-based therapies in development in patients who require additional LDL-C reduction
- To review the clinical significance of additional lipid lowering pathways, such as ezetimibe, in the management of patients with ACS
- Understand the implications of new guidelines for lipid management
Disclosures
Professor Chris Packard, MD: R&D Director, NHS Greater Glasgow & Clyde Health Board, Honorary Professor of Vascular Biochemistry, University of Glasgow - Consultant Clinical Scientist, Dept of Biochemistry NHS Greater Glasgow & Clyde Health Board
Funding
This EBAC accredited symposium was funded by unrestricted educational grants received from Novartis, MSD, Amgen
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The information and data provided in this program were updated and correct at the time of the program development, but may be subject to change.
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