IL-1β inhibitor has no positive effect on arterial structure or function
Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance
Choudhury RP, Birks JS, Mani V, et al.
J Am Coll Cardiol. 2016;68(16):1769
BackgroundSystemic markers of inflammation, such as c-reactive protein (CRP), are related to CV prognosis. Moreover, treatment strategies that lower CV risk have also been associated with a reduction of systemic inflammatory markers. However, it is not clear whether targeting inflammation reduces CV risk [1,2].
Atherosclerosis is well-established as a disease with an important inflammatory component. It has been investigated that interleukin (IL)-1β, a mediator of inflammation, is an important in the pathogenesis of atherosclerosis and its complications, as well as in the pathogenesis of type 2 diabetes mellitus (T2DM). The inhibition of IL-1β may favourably affect vascular disease progression [3,4].
In this placebo-controlled, phase II study, the effects of IL-1β inhibition with the human monoclonal antibody canakinumab on arterial (carotid arteries and aorta) structure and function was evaluated using MRI. Moreover, the effects of canakinumab on measures of diabetes control and on inflammation indicators were assessed in patients with atherosclerotic vascular disease and impaired glucose tolerance (IGT) or T2DM (n=189). Patients were 1:1 randomized to either placebo or canakinumab 150 mg monthly, for a duration of 12 months.
- Vessel wall area was used as a biomarker of atherosclerotic plaque burden. Baseline mean carotid wall areas were 27.7 ± 9.79 mm2 and 27.1 ± 9.6 mm2 (P = NS) for the canakinumab and placebo groups, respectively. Change in mean carotid artery wall area was –3.37 mm2 (P = 0.06) after 12 months for canakinumab versus placebo. Of note, there was an average increase (from baseline) in wall area for each of the left and right carotid arteries with placebo, but neither progression nor regression in the canakinumab group was observed.
- The vessel lumen area was not changed by canakinumab treatment.
- There was no statistically significant difference between canakinumab treatment and placebo in: wall area of the 3 aortic sites at either 3 or 12 months, change in aortic distensibility, and measures of pulsed wave velocity at either time point. Also no changes occurred in SBP or DBP at either 3 or 12 months.
- Compared with placebo, canakinumab reduced: high-sensitivity CRP (hs-CRP) at 3 months (geometric mean ratio [GMR]: 0.568; 95% CI: 0.436 - 0.740; P < 0.0001) and at 12 months (GMR: 0.56; 95% CI: 0.414 - 0.758; P = 0.0002), and IL-6 at the 3-month time point (GMR: 0.580; 95% CI: 0.483 - 0.697; P < 0.0001).
- Canakinumab had no effect on LDL-C or HDL-C levels compared with placebo at either of the 3- or 12-month time points. Treatment with canakinumab increased levels of triglycerides and total cholesterol. Lipoprotein(a) levels were reduced by canakinumab compared with placebo at 3 months (mean change –3.719 mg/dl, 95% CI: –6.809 to –0.628; P = 0.02) and at 12 months (mean change –4.300 mg/dl, 95% CI: –8.052 to –0.548; P = 0.025).
- Canakinumab had no significant effect compared with placebo on fasting blood glucose, HbA1c, HOMA–insulin resistance or HOMA-β, or 2-h glucose.
ConclusionIn patients with T2DM and established CV disease, the IL-1β inhibitor canakinumab reduced markers of inflammation (hs-CRP and IL-6) compared with placebo, modestly increased levels of triglycerides and total cholesterol, and reduced lipoprotein(a) levels. Although the effect on these markers, there was no obvious effect on measures of vascular structure or function of the carotid arteries and the aorta.
Editorial Comment In their editorial article, Zhao XQ et al congratulate the investigators for their study and point out the possible reasons for the disappointing results that include:
- poor subject selection
- limits of the imaging methodology
- suboptimal endpoints
- suboptimal dosing, or inadequate duration of treatment
- possibility of an incorrect hypothesis
Find this article online at JACC
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