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PCSK9 antibody therapy leads to effective and sustained LDL-c and Lp(a) decrease

Gaudet D, et al, Am J Cardiol, 2016

Effect of Alirocumab on Lipoprotein(a) Over ≥1.5 Years (from the Phase 3 ODYSSEY Program)


Gaudet D, Watts GF, Robinson JG, et al.
Am J Cardiol 2016; published online ahead of print
 

Background

In ten phase 3 ODYSSEY studies, alirocumab, a monoclonal antibody against PCSK9, was able to reduce LDL-c levels from baseline to up to 62% during 24 weeks. These studies predominantly involved patients at high CV risk [1,2]. According to a pooled analysis of three alirocumab phase 2 studies, the median Lp(a) reduction was 30% after 8 to 12 weeks of treatment, and in individual phase 3 studies, alirocumab reduced Lp(a) by an average of 25% to 30% within 24 weeks [3-5].
 
In this pooled analysis of ten phase 3 studies (LONG TERM, HIGH FH, COMBO I, FH I, FH II, COMBO II, OPTIONS I, OPTIONS II, ALTERNATIVE, MONO), the maintenance of the Lp(a)-lowering effect with alirocumab over 24 to 104 weeks was assessed in 4,915 participants.
 

Main results

 

Conclusion

The consistent reductions in Lp(a) observed across the studies suggest that PCSK9 inhibition with alirocumab not only effectively lowers LDL-c but also has a substantial, sustained effect on Lp(a).
 
Find this article online at Am J Cardiol
 

References

1. Cannon CP, Cariou B, Blom D, et al. Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBOII randomized controlled trial. EurHeart J 2015;36:1186e1194.
2. Farnier M, Jones P, Severance R, et al. Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: the ODYSSEY OPTIONS II randomized trial. Atherosclerosis 2016;244:138e146.
3. Kastelein JJ, Ginsberg HN, Langslet G, et al. ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia. Eur Heart J 2015;36:2996e3003.
4. Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015;372:1489e1499.
5. Gaudet D, Kereiakes DJ, McKenney JM, et al. Effect of alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials). Am J Cardiol 2014;114:711e715.